GSH 250™ 90 caps (Categories / Antioxidants) -- The Green Pharmacy Shopping Cart -- caps 90 250™ GSH

<A HREF="http://www.thegreenpharmacy.com" TITLE="The Green Pharmacy"><IMG SRC="https://store.nexternal.com/greenpharm/Logo-9thvector_Nexternal.jpg" ALT="The Green Pharmacy" NAME="The Green Pharmacy" BORDER=0></A> <H1>GSH 250™ 90 caps -- The Green Pharmacy Shopping Cart</H1> $67.50 -- Specially formulated to potentiate antioxidant protection <IMG SRC="https://store.nexternal.com/greenpharm/images/DL_GSH_250.jpg" ALIGN=right ALT="GSH 250™ 90 caps" NAME="GSH 250™ 90 caps" BORDER=0 HSPACE=10> <style>  </style> <h5 ALIGN="LEFT">Description</h5> GSH 250™, capsules, provided by Douglas Laboratories®, contain meaningful amounts of antioxidant nutrients including glutathione in its reduced active form, N-acetyl-L-cysteine, a biologically active precursor to intracellular glutathione, alpha-lipoic acid, and selenium. <h5 ALIGN="LEFT">Functions</h5> Body cells and tissues are threatened continuously by damage caused by toxic free radicals and reactive oxygen species (e.g., peroxides) which are produced during normal oxygen metabolism, by other chemical reactions, and by toxic agents in the environment. Free radicals are capable of disrupting metabolic activity and cell structure. When this occurs, additional free radicals are produced which, in turn, can result in more extensive damage to cells and tissues. The uncontrolled production of free radicals is thought to be a major contributing factor to many degenerative processes seen during aging. Glutathione is a naturally-occurring tripeptide of Lcysteine, L-glutamate and L-glycine. Glutathione is the essential cosubstrate for two major antioxidant enzymes in the body; glutathione peroxidase and glutathione reductase. As such, glutathione offers one mechanism for scavenging toxic free radicals. Glutathione is well absorbed in the intestine, and enters the blood and other extracellular compartments where it exerts much of its beneficial antioxidant effects. However, it can not effectively enter the cell. N-Acetylcysteine (NAC) is a precursor for the sulfur amino acid cysteine, and cysteine is used by the body to synthesize glutathione. In contrast to glutathione, NAC is efficiently transported into the cell where it is readily converted to L-cysteine for glutathione synthesis. NAC is well absorbed, and unlike L-cysteine, is virtually non-toxic. NAC is recognized as a safe, highly effective means of increasing intracellular glutathione stores. Aside from providing cysteine as a glutathione precursor, NAC also appears to have antioxidant properties by itself, and is a valuable sulfur donor for various metabolic needs. Alpha-lipoic acid is unique among biological antioxidants, because it is soluble in both water and lipids. This allows it to neutralize free radicals just about everywhere in the body, inside and outside the cells. Due to its unique sulfur- containing structure, alpha-lipoic acid can scavenge several types of free radicals, such as the highly reactive hydroxyl, and singlet oxygen free radicals. It is also capable of suppressing the generation of free radicals in the first place, since alpha-lipoic acid chelates transition metals, such as iron and copper. Because alpha-lipoic acid is involved in so many different antioxidant functions in virtually all body tissues, it has been called the universal antioxidant. Besides being a universal free radical scavenger, alpha-lipoic acid can also recharge other antioxidant systems throughout the body. It can extend the activity of vitamins C and E. and can also regenerate glutathione. Selenium is a cofactor to about 10 selenoproteins in the body; the most important of these appears to be glutathione peroxidase (GPX). GPX uses glutathione to reduce hydrogen peroxide and thus protect cells and plasma against free radical injury. GPX activity depends on an adequate supply of dietary selenium. <h5 ALIGN="LEFT">Indications</h5> GSH 250™ capsules may be a useful nutritional adjunct for individuals who wish to increase their intake of glutathione, cysteine-derived antioxidants, as well as other antioxidant nutrients. <h5 ALIGN="LEFT">Suggested Use</h5> Adults take 3 capsules daily or as directed by physician. <h5 ALIGN="LEFT">Side Effects/Warnings</h5> No adverse effects have been reported <h5 ALIGN="LEFT">Storage</h5> Store in a cool, dry place, away from direct light. Keep out of reach of children. <h5 ALIGN="LEFT">References:</h5> <ol> <li> Aruoma OI, Halliwell B, Hoey BM, et al. The antioxidant action of N-acetylcysteine: its reaction with hydrogen peroxide, hydroxyl radical, superoxide, and hypochlorous acid. Free Radic Biol Med 1989;6:593-7. </li> <li> Best TM, Fiebig R, Corr DT, et al. Free radical activity, antioxidant enzyme, and glutathione changes with muscle stretch injury in rabbits. J Appl Physiol 1999;87:74-82. </li> <li> Borcea V, Nourooz-Zadeh J, Wolff SP, et al. alpha-Lipoic acid decreases oxidative stress even in diabetic patients with poor glycemic control and albuminuria. Free Radic Biol Med 1999;26:1495-500. </li> <li> Boya P, de la Pena A, Beloqui O, et al. Antioxidant status and glutathione metabolism in peripheral blood mononuclear cells from patients with chronic hepatitis C. J Hepatol 1999;31:808-14. </li> <li> Dringen R, Pfeiffer B, Hamprecht B. Synthesis of the antioxidant glutathione in neurons: supply by astrocytes of CysGly as precursor for neuronal glutathione. J Neurosci 1999;19:562-9. </li> <li> Hagen TM, Ingersoll RT, Lykkesfeldt J, et al. (R)-alpha-lipoic acid-supplemented old rats have improved mitochondrial function, decreased oxidative damage, and increased metabolic rate. Faseb J 1999;13:411-8. </li> <li> Kagan VE, Shvedova A, Serbinova E, et al. Dihydrolipoic acid--a universal antioxidant both in the membrane and in the aqueous phase. Reduction of peroxyl, ascorbyl and chromanoxyl radicals. Biochem Pharmacol 1992;44:1637-49. </li> <li> Kamei A. Glutathione levels of the human crystalline lens in aging and its antioxidant effect against the oxidation of lens proteins. Biol Pharm Bull 1993;16:870-5. </li> <li> Lapenna D, de Gioia S, Ciofani G, et al. Glutathione-related antioxidant defenses in human atherosclerotic plaques. Circulation 1998;97:1930-4. </li> <li> Navarro J, Obrador E, Carretero J, et al. Changes in glutathione status and the antioxidant system in blood and in cancer cells associate with tumour growth in vivo. Free Radic Biol Med 1999;26:410-8.</li> </ol> 3 Capsules Contain:<table width="351" cellpadding="0" cellpadding="0"> <tr> <td width="270" background="/images/dots2.gif" nowrap> Glutathione</td><td width="75" background="/images/dots2.gif" align="right" nowrap> 250 mg</td></tr> <tr> <td width="270" background="/images/dots2.gif" nowrap> N-acetyl-L-cysteine</td><td width="75" background="/images/dots2.gif" align="right" nowrap> 250 mg</td></tr> <tr> <td width="270" background="/images/dots2.gif" nowrap> Alpha-lipoic acid</td><td width="75" background="/images/dots2.gif" align="right" nowrap> 200 mg</td></tr> <tr> <td width="270" background="/images/dots2.gif" nowrap> Parsley</td><td width="75" background="/images/dots2.gif" align="right" nowrap> 150 mg</td></tr> <tr> <td width="270" background="/images/dots2.gif" nowrap> Spinach</td><td width="75" background="/images/dots2.gif" align="right" nowrap> 50 mg</td></tr> <tr> <td width="270" background="/images/dots2.gif" nowrap> Riboflavin</td><td width="75" background="/images/dots2.gif" align="right" nowrap> 25 mg</td></tr> <tr> <td width="270" background="/images/dots2.gif" nowrap> Glycine</td><td width="75" background="/images/dots2.gif" align="right" nowrap> 5 mg</td></tr> <tr> <td width="270" background="/images/dots2.gif" nowrap> Glutamine</td><td width="75" background="/images/dots2.gif" align="right" nowrap> 5 mg</td></tr> <tr> <td width="270" background="/images/dots2.gif" nowrap> Cysteine</td><td width="75" background="/images/dots2.gif" align="right" nowrap> 5 mg</td></tr> <tr> <td width="270" background="/images/dots2.gif" nowrap> Selenium</td><td width="75" background="/images/dots2.gif" align="right" nowrap> 25 mcg</td></tr> </table> *These statements have not been evaluated by the Food and Drug Administration. 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