
Chromium Picolinate 250 mcg. is a trace element
supplement that contains chromium bound to picolinic acid, a highly biologically
active form of this mineral. Chromium is an essential trace mineral that
potentiates insulin action and thus influences carbohydrate, protein, and fat
metabolism. The biologically active form of chromium, sometimes called glucose
tolerance factor (GTF), occurs naturally in brewers yeast. GTF has been proposed
to be a complex of chromium, nicotinic acid (vitamin B- 3), and possibly the
amino acids glycine, cysteine, and glutamic acid. Although many attempts have
been made to isolate or synthesize natural GTF, none have been entirely
successful. Adequate chromium nutrition is essential for the formation of GTF
and subsequent control of blood glucose levels. Studies have shown that
supplemental chromium may be useful for the maintenance of healthy blood sugar.
Chromium appears to act by increasing insulin binding, insulin receptor numbers,
and rate of insulin receptor phosphorylation. Chromium absorption is typically
less than 2% efficient and variable depending on its chemical form. Studies have
demonstrated that chromium picolinate has a bioavailability comparable to that
of chromium polynicotinate, and higher than that of chromium chloride. Tissues
retain anywhere from 2 to 8 times more chromium from chromium picolinate
compared to chromium chloride. The typical dietary chromium intake in the U.S.
can vary considerably depending on eating habits. Meats and unrefined whole
grain cereal products, especially bran, are good sources of chromium. However,
most self-selected diets contain less than 50 mcg per day, which is below the
minimum of the Estimated Safe and Adequate Daily Dietary Intake established by
the National Research Council, Food and Nutrition Board. Chromium requirements
may be increased with high intake of refined carbohydrates and simple sugars,
strenuous physical exercise or work, infection, or physical trauma. Chromium Picolinate 250 mcg. may be useful as a
daily supplement for individuals who wish to supplement their intake of chromium
or who have a demonstrated need for supplemental chromium in its active form due
to dietary deficiency or impaired metabolism. Adults take 1 capsule daily or as directed by
physician. No adverse effects have been reported. Store in a cool, dry place, away from direct
light. Keep out of reach of children. Anderson RA. Chromium, glucose intolerance and diabetes. J
Am Coll Nutr 1998;17:548-55. Anderson RA, Bryden NA, Polansky MM. Lack of toxicity of
chromium chloride and chromium picolinate in rats. J Am Coll Nutr
1997;16:273-9. Anderson RA, Cheng N, Bryden NA, et al. Elevated intakes of
supplemental chromium improve glucose and insulin variables in individuals
with type 2 diabetes. Diabetes 1997;46:1786-91. Bahadori B, Wallner S, Schneider H, et al. [Effect of
chromium yeast and chromium picolinate on body composition of obese,
nondiabetic patients during and after a formula diet]. Acta Med Austriaca
1997;24:185-7. Fox GN, Sabovic Z. Chromium picolinate supplementation for
diabetes mellitus. J Fam Pract 1998;46:83-6. Hoeger WW, Harris C, Long EM, et al. Four-week
supplementation with a natural dietary compound produces favorable changes
in body composition. Adv Ther 1998;15:305-14. Lee NA, Reasner CA. Beneficial effect of chromium
supplementation on serum triglyceride levels in NIDDM. Diabetes Care
1994;17:1449-52. Lien TF, Horng YM, Yang KH. Performance, serum
characteristics, carcase traits and lipid metabolism of broilers as affected
by supplement of chromium picolinate. Br Poult Sci 1999;40:357-63. McCarty MF. High-dose biotin, an inducer of glucokinase
expression, may synergize with chromium picolinate to enable a definitive
nutritional therapy for type II diabetes. Med Hypotheses 1999;52:401- 6.
Preuss HG, Grojec PL, Lieberman S, et al. Effects of
different chromium compounds on blood pressure and lipid peroxidation in
spontaneously hypertensive rats. Clin Nephrol 1997;47:325-30. Vincent JB. The biochemistry of chromium. J Nutr
2000;130:715-8. *These statements have not been evaluated by the Food and Drug
Administration. This product is not intended to diagnose, treat, cure, or
prevent any disease.
Description
Functions
Indications
Suggested Use
Side Effects/Warnings
Storage
References:
Each Capsule
Contains:
Chromium (Picolinate)
250 mcg
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