
Boswellia AKBA supports the structural integrity,
motility and comfort of joint cartilage and promotes gastrointestinal health and
cell health.* Joint Support: Boswellic acids maintain
healthy 5–lipoxygenase (5–LO) activity, moderating leukotriene biosynthesis.
Data suggests that of the various boswellic acids, 3–acetyl–11–keto–beta–boswellic
acid, or AKBA, is considered the most powerful. AKBA helps preserve the
structural integrity of joint cartilage, promotes gastrointestinal health and
maintains a healthy immune mediator cascade at the cellular level.* Immune Support: In addition to maintaining
healthy 5–LO activity, exciting new research has revealed that 5–LOXIN® may
influence healthy gene expression of immune compounds. In studies, 5–LOXIN® has
demonstrated the potential to support joint motility and comfort, in part by
promoting a healthy immune response. It may also play a role in maintaining
healthy matrix metalloproteinase (MMP) activity, supporting connective tissue
structural composition.* Gastrointestinal Support: A randomized
double blind study involving 102 individuals revealed that AKBA supports
gastrointestinal health. Further studies have indicated that AKBA may provide
gastrointestinal support by maintaining healthy immune activity in the
endothelial lining of the digestive tract. Moreover, studies suggest AKBA
supports healthy cell signaling and cell cycle function for high capacity
cellular support.* 5–LOXIN® is a patent pending boswellia extract
providing ten times as much AKBA as typical boswellia extracts. The extract is
derived from the gum resin of the boswellia serrata plant, commonly known as
frankincense. It is standardized to contain 30% AKBA
(3-acetyl-11-keto-betaboswellic acid). Vitamin C (ascorbyl palmitate) is derived
from corn dextrose fermentation and palm oil. Hypo-allergenic plant fiber is
derived from pine cellulose. † AKBA boswellia serrata extract. 5-LOXIN® is a
registered trademark of PL Thomas & Co., Inc. International patents pending. Pure Encapsulations recommends 1 capsule per day,
with a meal. Not to be taken by pregnant or lactating women.
Rare side effects of boswellia include diarrhea, skin rash, acid reflux and
nausea and may be contraindicated in those with pre-existing gastritis or
gastro-esophageal reflux disease (GERD). Studies suggest boswellia moderates 5-lipoxygenase
and therefore may interact with leukotriene inhibitors. Krieglstein CF et al. Acetyl-11-keto-beta-boswellic acid, a
constituent of a herbal medicine from Boswellia serrata resin, attenuates
experimental ileitis. Int J Colorectal Dis. 2001 Apr;16(2):88 Gerhardt H, Seifert F, Buvari P, Vogelsang H, Repges R.
Therapy of active Crohn disease with Boswellia serrata extract H 15. Z
Gastroenterol. 2001 Jan;39(1):11-7. Park YS et al. Acetyl-11-keto-beta-boswellic acid (AKBA) is
cytotoxic for meningioma cells and inhibits phosphorylation of the
extracellular-signal regulated kinase 1 and 2. Adv Exp Med Biol.
2002;507:387-93. Kimmatkar N, Thawani V, Hingorani L, Khiyani R. Efficacy and
tolerability of Boswellia serrata extract in treatment of osteoarthritis of
knee-a randomized double blind placebo controlled trial. Phytomedicine. 2003
Jan;10(1):3-7. Hostanska K, Daum G, Saller R. Cytostatic and
apoptosis-inducing activity of boswellic acids toward malignant cell lines
in vitro. Anticancer Res. 2002 Sep-Oct;22(5):2853-62. Hoernlein RF et al. Acetyl-11-keto-beta-boswellic acid
induces apoptosis in HL-60 and CCRF-CEM cells and inhibits topoisomerase I.
Pharmacol Exp Ther. 1999 Feb;288(2):613-9. Pungle P, Banavalikar M, Suthar A, Biyani M, Mengi S.
Immunomodulatory activity of boswellic acids of Boswellia serrata Roxb.
Indian J Exp Biol. 2003 Dec;41(12):1460-2. Healthnotes Clinical Essentials. Copyright 2004. Healthnotes,
Inc. 30 mg. 10 mg.
What Is It?
Uses For Boswellia AKBA
What Is The Source?
Recommendations
Are There Any Potential Side Effects Or Precautions?
Are There Any Potential Drug Interactions?
References:
each vegetable capsule contains:
boswellia serrata extract (gum resin)†
100 mg.
(standardized to contain 30%
3–acetyl–11–keto–beta–
boswellic acid (AKBA))
vitamin C (as ascorbyl palmitate)
(hypo–allergenic plant fiber added to
complete capsule volume requirement)
1 capsule per day, with a meal.
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