
Milk Thistle Max-V vegetarian capsules, provided
by Douglas Laboratories, contain 250 mg of milk thistle extract, standardized to
contain a minimum of 80% of the flavonoid silymarin. Milk thistle, a common herb native to the
Mediterranean, has been widely used for its nutritional support of liver
function for over 2,000 years. Seeds of the dried milk thistle flower are rich
in silymarin, a bioflavonoid complex of three flavonolignins: silybin,
silydianin, and silychristin. Silymarin is responsible for milk thistle’s
powerful protective and regenerative activities in the liver. The liver is the
body’s detoxifying organ, disabling toxins such as ethanol, environmental
poisons, pesticides, and certain pharmaceuticals. In addition to its
detoxification properties, the liver plays an essential role in protein,
carbohydrate, and lipid metabolism, cholesterol synthesis, bile secretion, and
storage of fat-soluble vitamins. When damaged or diseased, the liver’s ability
to eliminate toxins and perform its numerous other functions may be severely
impaired. Silymarin has been shown to support and enhance normal, healthy liver
function through three primary actions. By binding to the outer cell membrane,
silymarin prevents harmful toxins from entering the cell. Silymarin further
protects the liver as an important component of the liver’s antioxidant defense.
The liver generates potentially damaging, toxic free radicals and reactive
oxygen species (e.g. peroxides) as a result of its normal metabolic and
detoxifying functions. Left unchecked, these radicals can damage the cell
structure and interfere with normal cell functions. Fortunately, silymarin
provides support for free radical damage. Furthermore, silymarin enhances levels
of glutathione and superoxide dismutase, two primary antioxidants in the liver.
In addition to its protective functions, silymarin stimulates damaged liver
cells to regenerate. In the cell nucleus, silymarin augments the production of
ribosomes, stimulating protein synthesis in the damaged cell. This results in
expedited cell regeneration, the replacement and repair of damaged cells. Milk Thistle Max-V vegetarian capsules may be a
useful nutritional supplement for individuals who wish to enhance healthy
hepatic function through the natural protective and regenerative properties of
this herb. Adults take 1 capsule twice daily between meals or
as directed by physician. No adverse effects have been reported. Store in a cool, dry place, away from direct
light. Keep out of reach of children. Allain, H, Schuck, S, Lebreton, S, Strenge-Hesse, A, Braun,
W, Gandon, JM, Brissot, P. Aminotransferase levels and silymarin in de novo
tacrine-treated patients with Alzheimer's disease. Dement Geriatr Cogn
Disord 1999;10:181-5. Bass, NM. Is there any use for nontraditional or alternative
therapies in patients with chronic liver disease? [In Process Citation].
Curr Gastroenterol Rep 1999;1:50-6. Berkson, BM. A conservative triple antioxidant approach to
the treatment of hepatitis C. Combination of alpha lipoic acid (thioctic
acid), silymarin, and selenium: three case histories. Med Klin 1999;94 Suppl
3:84-9. Edwards, J, Grange, LL, Wang, M, Reyes, E. Fetoprotectivity
of the flavanolignan compound siliphos against ethanol- induced toxicity [In
Process Citation]. Phytother Res 2000;14:517-21. Farghali, H, Kamenikova, L, Hynie, S, Kmonickova, E.
Silymarin effects on intracellular calcuim and cytotoxicity: a study in
perfused rat hepatocytes after oxidative stress injury. Pharmacol Res
2000;41:231-7. Flora, K, Hahn, M, Rosen, H, Benner, K. Milk thistle (Silybum
marianum) for the therapy of liver disease [see comments]. Am J
Gastroenterol 1998;93:139-43. Kropacova, K, Misurova, E, Hakova, H. Protective and
therapeutic effect of silymarin on the development of latent liver damage.
Radiats Biol Radioecol 1998;38:411-5. Par, A, Roth, E, Rumi, G, Jr., Kovacs, Z, Nemes, J, Mozsik,
G. [Oxidative stress and antioxidant defense in alcoholic liver disease and
chronic hepatitis C]. Orv Hetil 2000;141:1655-9. Zhao, J, Sharma, Y, Agarwal, R. Significant inhibition by
the flavonoid antioxidant silymarin against 12-O-tetradecanoylphorbol
13-acetate-caused modulation of antioxidant and inflammatory enzymes, and
cyclooxygenase 2 and interleukin-1alpha expression in SENCAR mouse
epidermis: implications in the prevention of stage I tumor promotion. Mol
Carcinog 1999;26:321-33. Zhao, J, Agarwal, R. Tissue distribution of silibinin, the
major active constituent of silymarin, in mice and its association with
enhancement of phase II enzymes: implications in cancer chemoprevention.
Carcinogenesis 1999;20:2101-8. *These statements have not been evaluated by the Food and Drug
Administration. This product is not intended to diagnose, treat, cure, or
prevent any disease.
Description
Functions
Indications
Suggested Use
Side Effects/Warnings
Storage
References:
Each Vcaps
Vegetarian capsule contains:
Milk Thistle
250 mg
(Silybum marianum)
Standardized to 80% Silymarin
(North America,
Europe, moderate climates)
In a 100 mg base of non-standardized Milk
Thistle
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