
BroccoSabi™, provided by Douglas Laboratories®, is
a unique combination of true Japanese wasabi with a specially standardized
broccoli sprout concentrate to support the body’s natural detoxification
processes.† As the body’s main detoxification organ, the liver
is responsible for removing all potentially detrimental molecules such as
alcohol, drugs and air pollutants from the blood stream. This detoxification
process occurs in 2 phases, known as Phase I and Phase II. During Phase I,
enzymes such as cytochrome P-450 mixed-function oxidases are activated, causing
potential toxins to be transformed by oxidation, reduction or hydroxylation into
biological intermediates. Phase II enzymes, including quinone reductase and
glutathione S-transferase then cause these intermediates to be further
transformed into substances that are less toxic, water-soluble, and can be
safely eliminated. Supporting phase II enzymes such as quinine reductase and
glutathione S-transferase is a critical part of maintaining normal liver health. Certain naturally occurring compounds have the
ability to stimulate these detoxification pathways, including a group of
compounds called isothiocyanates (ITCs). Found primarily in cruciferous
vegetables, including broccoli and cauliflower, ITCs are recognized for the
important roles they play in the body’s antioxidant and normal detoxifying
processes.† BroccoSabi provides important ITCs from both Wasabia japonica and
broccoli sprouts. Wasabi is a familiar green condiment in dishes
that contain sushi and sashimi. While many people are familiar with the
condiment’s spicy, pungent taste, most “wasabi” that is served in restaurants is
often not true Japanese wasabi, but instead, American horseradish mixed with
starch and coloring. Wasabia japonica (true wasabi) is much different from
American horseradish and is generally not found outside of Japan. Wasabia, a
member of the cruciferous vegetable family, contains long chain ITCs - forms of
ITCs that are thought to be 10-25 times more potent in the detoxification
process than most ITCs found in cruciferous vegetables. These long chain ITCs
are unique to Wasabia and are not commonly found in other cruciferous
vegetables. The Wasabia used in BroccoSabi is Sawa™ Wasabia japonica, and is
hydroponically grown under highly controlled conditions. This results in a
consistent and pure material. Sulforaphane, an ITC found in broccoli, has been
studied for its use in supporting normal detoxification processes and helping to
maintain antioxidant protection of the body.† Sulforaphane has been found to
significantly increase the activity of Phase II enzymes. Recent evidence
indicates that sulforaphane can also play important roles in gastrointestinal
health as well as helping to support normal cell growth and division.† Among
cruciferous vegetables, broccoli sprouts have been found to contain some of the
most concentrated levels of sulfurophane. BroccoSabi may be a useful dietary supplement for
individuals wishing to support the body’s normal detoxification processes. Adults take 2 capsules daily with meals or as
directed by physician. No adverse side effects reported. Store in a cool, dry place, away from direct
light. Keep out of reach of children. Galan MV, Kishan AA, Silverman AL. Oral broccoli sprouts for
the treatment of Helicobacter pylori infection: a preliminary report. Dig
Dis Sci. 2004 Aug;49(7-8):1088-90. Gao X, Talalay P. Induction of phase 2 genes by sulforaphane
protects retinal pigment epithelial cells against photooxidative damage.
Proc Natl Acad Sci U S A. 2004 Jul 13;101(28):10446-5. Singh SV, Herman-Antosiewicz A, Singh AV, Lew KL, Srivastava
SK, Kamath R, Brown KD, Zhang L, Baskaran R. Sulforaphane-induced G2/M phase
cell cycle arrest involves checkpoint kinase 2-mediated phosphorylation of
cell division cycle 25C. J Biol Chem. 2004 Jun 11;279(24):25813-22. Manesh C, Kuttan G Effect of naturally occurring allyl and
phenyl isothiocyanates in the inhibition of experimental pulmonary
metastasis induced by B16F-10 melanoma cells. Fitoterapia. 2003
Jun;74(4):355-63. Morimitsu Y, Hayashi K, Nakagawa Y, Horio F, Uchida K, Osawa
T. Antiplatelet and anticancer isothiocyanates in Japanese domestic
horseradish, wasabi. Biofactors,. 2000;13(1-4):271-6. *These statements have not been evaluated by the Food and Drug
Administration. This product is not intended to diagnose, treat, cure, or
prevent any disease.
Description
Functions
Indications
Suggested Use
Side Effects/Warnings
Storage
References:
Each 2 vegetarian
capsules contain:
Wasabia japonica (rhizome)
400 mg
(Providing 600 mcg
of isothiocyanates as
Allyl ITC, 3-butenyl
ITC, and 4-pentenyl ITC)
Broccoli powder (sprout)
400 mg
(BroccoPhane™)
(Standardized to
1,600 mcg of
sulforaphane)
BroccoPhane™ is a trademark of Cyvex
Nutrition
Sawa™ is a trademark of New Zealand Wasabi,
Ltd.
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