
Biodophilus™, provided by Douglas Laboratories, is
a highly concentrated combination of probiotic Lactobacillus acidophilus and
Lactobacillus casei subsp. Rhamnosus, which provides a minimum of 10 billion
viable microorganisms per gram. Each 280 mg capsule contains 2.8 billion viable
microorganisms. Unlike many other probiotic dietary supplements
provided in powder form or gelatin capsules, Biodophilus is enteric coated with
inert cellulose. This prevents dissolution in the stomach, protects the
microorganisms from the damaging effects of stomach acid, and ensures effective
release in the intestine where the probiotics are able to survive and colonize. Biodophilus is free of preservatives and common
allergens, including dairy, wheat, and soya. The probiotic cultures are grown on
a neutral maltodextrin base. The microorganisms are harvested and freeze-dried
when they are at their maximum concentration. Each batch is assayed to guarantee
consistent high potency, and low moisture content provides for long shelf life
even at room temperatures. Oral supplements of live, beneficial intestinal
microorganisms for nutritional health and well-being are known as probiotics.
Probiotic dietary lactobacilli colonize the intestinal tract, depending on the
specific bacterium-to-host affinity. Bacteria are continually in competition for
colonization space. The original bacterial colonies have an advantage over
transient bacteria; however, the composition of the intestinal microflora is
dynamic and constantly changing. If harmful microorganisms proliferate, as in
the case of diarrheal or fungal infections (e.g., Candida albicans), the
equilibrium is disturbed, and it becomes difficult even for indigenous bacteria
to maintain their necessary territory to colonize the intestine. Antibiotics
tend to kill off both beneficial and harmful bacteria, thus may also disturb the
normal, healthy balance of intestinal microorganisms. When potent, enteric
coated probiotic supplements, such as Biodophilus, are supplied regularly,
chances are greatly increased for establishing a healthy population of
beneficial intestinal microorganisms. Once established, a normal intestinal
microflora rich in lactobacilli creates acidic conditions that are unfavorable
for the settlement of pathogenic microorganisms. Biodophilus may be a useful dietary supplement for
those who wish to support the intestinal microflora with meaningful amounts of
beneficial microorganisms. One capsule daily after a meal, or as directed by
physician. For more intensive supplementation, begin with one capsule daily for
two weeks, then increase to up to three capsules per day after meals.
Biodophilus may be taken safely with other dietary probiotic supplements, such
as NutraFlora®FOS or Intestamine™. No adverse side effects have been reported. Store in a cool, dry place, away from direct
light. May be stored in refrigerator. Keep out of reach of children. Balli F, Bertolani P, Giberti G, Amarri S. High-dose oral
bacteriatherapy for chronic non-specific diarrhea of infancy. Pediatr Med
Chir 1992;14:13-15. Contardi I. Oral bacterial therapy in prevention of
antibiotic-induced diarrhea in childhood. Clin Ter 1991;136:409-413. Fitzsimmons N, Berry DR. Inhibition of Candida albicans by
Lactobacillus acidophilus: evidence for the involvement of a peroxidase
system. Microbios 1995;80:125-133. Gorbach SL. Lactic acid bacteria and human health. Ann Med
1990;22:37-41. Hilton E, Isenberg HD, Alperstein P, France K, Borenstein
MT. Ingestion of yogurt containing Lactobacillus acidophilus as prophylaxis
for candidal vaginitis. Ann Intern Med 1992;116:353-357. Hove H, Nordgaard-Andersen I, Mortensen PB. Effect of lactic
acid bacteria on the intestinal production of lactate and short-chain fatty
acids, and the absorption of lactose. Am J Clin Nutr 1994;59:74- 9. Kuvaeva IB, Orlova NG, Veselova OL, Kuznezova GG, Borovik
TE. Microecology of the gastrointestinal tract and the immunological status
under food allergy. Nahrung 1995;28:689-693. Lidbeck A, Edlund C, Gustafsson JA, Kager L, Nord CE. Impact
of Lactobacillus acidophilus on the normal intestinal microflora after
administration of two antimicrobial agents. Infection 1995;16:329- 36. Lidbeck A, Gustafsson JA, Nord CE. Impact of Lactobacillus
acidophilus supplements on the human oropharyngeal and intestinal microflora.
Scand J Infect Dis 1995;19:531-537. Lidbeck A, Nord CE, Gustafsson JA, Rafter J. Lactobacilli,
anticarcinogenic activities and human intestinal microflora. Eur J Cancer
Prev 1992;1:341-353. Lin SY, Ayres JW, Winkler W, Jr., Sandine WE. Lactobacillus
effects on cholesterol: in vitro and in vivo results. J Dairy Sci
1989;72:2885-2899. Rapoport L, Levine WI. Treatment of oral ulceration with
lactobacillus tablets. Oral Surg Oral Med Oral Pathol 1965;20:591-593. Salminen E, Elomaa I, Minkkinen J, Vapaatalo H, Salminen S.
Preservation of intestinal integrity during radiotherapy using live
Lactobacillus acidophilus cultures. Clin Radiol 1988;39:435-437. Tankanow RM, Ross MB, Ertel IJ, Dickinson DG, McCormick LS,
Garfinkel JF. A double-blind, placebo-controlled study of the efficacy of
Lactinex in the prophylaxis of amoxicillin-induced diarrhea. DICP
1990;24:382-384. Tihole F. Possible treatment of AIDS patients with live
lactobacteria. Med Hypotheses 1988;26:85-88. Vincent JG et al. Anti-bacterial activity associated with
Lactobacillus acidophilus. J Bacteriol 1959;78:477-484. *These statements have not been evaluated by the Food and Drug
Administration. This product is not intended to diagnose, treat, cure, or
prevent any disease.
Description
Functions
Indications
Suggested Use
Side Effects/Warnings
Storage
References:
Each capsule
contains:
2.8 billion* viable Lactobacillus
acidophilus and
Lactobacillus casei subsp. rhamnosus
microorganisms (10 billion per gram).
*Guaranteed minimum potency at time of
manufacture.
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