
5-HTP Plus Formula capsules, provided by Douglas
Laboratories, contain 75 mg of natural L-5- hydroxytryptophan (5-HTP) extracted
from seeds of the Griffonia plant, together with 7.5 mg of pyridoxal-5-phosphate
and 50 mg of a proprietary blend of the neurotransmitters L-tyrosine and
Lglutamine. This product has been certified to be free of a contaminant, peak
"x", implicated in a past incidence of dietary tryptophan-associated
eosinophilia myalgia syndrome (EMS). Serotonin, an important brain neurotransmitter, is
key in the regulation of appetite, mood, and melatonin production. The presence
of serotonin in the brain is associated with a balanced emotional state. This is
achieved in part by decreasing the activity of certain excitatory hormones,
including dopamine and noradrenaline. Serotonin also acts as a satiety signal in
the brain, thereby naturally regulating food intake. Additionally, as a
precursor of melatonin, serotonin is involved in regulating sleep patterns.
Serotonin is unable to cross the blood-brain barrier and is therefore
synthesized in the brain. Tryptophan, an essential amino acid, is a precursor
for the synthesis of serotonin. Tryptophan crosses the blood-brain barrier and
is converted to L-5-hydroxytryptophan, which in turn is converted into
serotonin. Unfortunately, tryptophan faces many obstacles during its journey
into brain tissue. First, dietary intake directly affects body levels of
tryptophan, as the body can not endogenously produce it. High protein diets
often provide greater amounts of tryptophan, yet higher carbohydrate diets
appear to enhance tryptophan uptake into the brain. Secondly, tryptophan must
compete with other amino acids for entry into the brain. Finally, tryptophan may
be taken up by other tissues for protein or niacin synthesis, and thus is not
exclusively for use by the brain. As a metabolic intermediate in the conversion
of tryptophan into serotonin, 5-HTP can also serve as a precursor of serotonin.
5-HTP offers a number of advantages over tryptophan. 5-HTP is derived naturally
from the seeds of the Griffonia plant, unlike tryptophan which is produced
synthetically or through bacterial fermentation. 5-HTP crosses into the brain
more readily than tryptophan as it is able to cross the blood-brain barrier
without competition for uptake. 5- HTP is significantly more effective than
tryptophan; one 50 mg capsule of 5-HTP is roughly equivalent to 500 mg of
tryptophan. Finally, research studies have shown 5-HTP to be safe at levels as
high as 900 mg. As a result, 5-HTP is a safe and effective means of increasing
brain serotonin levels. 5-HTP Plus Formula capsules may be a useful
nutritional supplement for individuals wishing to obtain the benefits of this
well-documented plant extract to increase their levels of brain serotonin. One to two capsules per day, between meals or as
directed by a physician. Vitamin B6 is necessary for the conversion of 5-HTP to
serotonin. Thus, an adequate intake of vitamin B6 is necessary to derive optimal
benefits of 5-HTP. No adverse side effects reported. Store in a cool, dry place, away from direct
light. Keep out of reach of children. Agren H, Reibring L, Hartvig P, Tedroff J, Bjurling P,
Hornfeldt K, Andersson Y, Lundqvist H, Langstrom B. Low brain uptake of
L-[11C]5-hydroxytryptophan in major depression: a positron emission
tomography study on patients and healthy volunteers. Acta Psychiatr Scand
1991;83:449-55. Alvarado R, Contreras S, Segovia-Riquelme N, Mardones J.
Effects of serotonin uptake blockers and of 5-hydroxytryptophan on the
voluntary consumption of ethanol, water and solid food by UChA and UChB
rats. Alcohol 1990;7:315-9. Angel I, Taranger MA, Claustre Y, Scatton B, Langer SZ.
Anorectic activities of serotonin uptake inhibitors: correlation with their
potencies at inhibiting serotonin uptake in vivo and 3Hmazindol binding in
vitro. Life Sci 1988;43:651-8. Birdsall TC. 5-Hydroxytryptophan: a clinically-effective
serotonin precursor. Altern Med Rev 1998;3:271-80. Blundell JE. Serotonin and appetite. Neuropharmacology
1984;23:1537-51. Blundell JE, Leshem MB. The effect of 5-hydroxytryptophan on
food intake and on the anorexic action of amphetamine and fenfluramine. J
Pharm Pharmacol 1975;27:31-7. Cangiano C, Ceci F, Cairella M, Cascino A, Del Ben M,
Laviano A, Muscaritoli M, Rossi-Fanelli F. Effects of 5-hydroxytryptophan on
eating behavior and adherence to dietary prescriptions in obese adult
subjects. Adv Exp Med Biol 1991;294:591-3. Cangiano C, Ceci F, Cascino A, Del Ben M, Laviano A,
Muscaritoli M, Antonucci F, Rossi-Fanelli F. Eating behavior and adherence
to dietary prescriptions in obese adult subjects treated with 5-
ydroxytryptophan. Am J Clin Nutr 1992;56:863-7. Ceci F, Cangiano C, Cairella M, Cascino A, Del Ben M,
Muscaritoli M, Sibilia L, Rossi Fanelli F. The effects of oral 5-
hydroxytryptophan administration on feeding behavior in obese adult female
subjects. J Neural Transm 1989;76:109-17. Ernouf D, Daoust M, Poulain D, Narcisse G. Triptosine, an
L-5- hydroxytryptophan derivative, reduces alcohol consumption in
alcohol-preferring rats. Alcohol Alcohol 1992;27:273-6. Ferstrom JD. Modification of brain serotonin by the diet.
Annu Rev Med 1974;25:1-8. Fletcher PJ, Burton MJ. Dissociation of the anorectic
actions of 5- HTP and fenfluramine. Psychopharmacology 1986;89:216-20. Martinelli I, Mainini E, Mazzi C. [Effect of
5-hydroxytryptophan on the secretion of PRL, GH, TSH and cortisol in
obesity]. Minerva Endocrinol 1992;17:121-6. Turner P, Bichi LA, Slusarczyk H, Franklin CS. The
peripheral actions of antiobesity drugs. Int J Obes 1982;6:411-5. *These statements have not been evaluated by the Food and Drug
Administration. This product is not intended to diagnose, treat, cure, or
prevent any disease.
Description
Functions
Indications
Suggested Use
Side Effects/Warnings
Storage
References:
Each Vcaps
Vegetarian Capsule Contains:
L-5-hydroxytryptophan
75 mg.
Pyridoxal-5-Phosphate
7.5 mg.
Proprietary Blend
50 mg.
L-tyrosine and
L-glutamine
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