
Copper amino acid chelate, provided by Douglas
Laboratories, is a patented, nutritionally functional bis-glycinate chelate
(Albion Labs) with excellent bioavailability. Each tablet delivers 2 mg of
elemental copper. Copper is an essential trace element and functions
as a cofactor of many enzymes involved in antioxidant defense (superoxide
dismutase), connective tissue metabolism (lysyl oxidase), and amine metabolism
(amine oxidases). Superoxide dismutase (SOD) is a key antioxidant enzyme in the
body’s cellular fluid (the cytosol) and mitochondria (the cell’s powerhouses).
SOD destroys harmful superoxide anions that are either generated during normal
energy metabolism or coming from environmental pollution. Cytosolic SOD activity
is dependent on sufficient levels of copper and zinc. Many studies have shown
that increasing dietary intake of these essential trace elements may increase
the activity of SOD considerably. As the essential cofactor of several amine
oxidases, copper assumes a pivotal role in the metabolism and degradation of
amines. Monoamine oxidase is involved in the inactivation of catecholamines. It
reacts with substances such as serotonin, norepinephrine, tyramine, and
dopamine. Diamine oxidase inactivates histamine and polyamines. Histamine is
produced by the immune system during allergic reactions in response to antigens.
Lysyl oxidase acts on the lysyl side chains of collagen and elastin, providing
the basis for cross-link formation within connective tissues. Copper is also important in many aspects of iron
metabolism (ceruloplasmin, ferroxidase), mitochondrial energy and phospholipid
metabolism (cytochrome c oxidase), and dopamine metabolism (dopamine â-
hydroxylase, tyrosinase). In the nervous system, copper is required for myelin
formation and maintenance, as well as for normal neurotransmission. Absorption
of free, ionic copper from foods is about 30- 40% efficient, and can be severely
compromised by free zinc and some antagonistic ligands in food, such as phytate.
Compared to free copper, the copper amino acid chelate is more bioavailable and
less influenced by antagonistic factors. Several studies showed that the Albion
chelate leads to excellent tissue retention of copper, as evidenced by effective
stimulation of SOD activity. Copper may be a useful nutritional adjunct for
individuals who wish to increase their intake of copper. One tablet daily as a dietary supplement, or as
directed by a physician. Take with food. No adverse effects have been reported. Store in a cool, dry place, away from direct
light. Keep out of reach of children. Danks DM. Copper deficiency in humans. Ann Rev Nutr
1988;8:235- 237. Kivirikko KI, Peltonen L. Abnormalities in copper metabolism
and disturbances in the synthesis of collagen and elastin. Med Biol
1982:60:45-48. Klevay LM. Copper and ischemic heart disease. Biol Trace
Elem Res 1983;5:245-255. Klevay LM et al. Increased cholesterol in a young man during
experimental copper depletion. Metabolism 1984;33:1112-1118. Uauy R et al. Red cell superoxide dismutase activity as an
index of human copper nutrition. J Nutr 1985;115:1650-1655. *These statements have not been evaluated by the Food and Drug
Administration. This product is not intended to diagnose, treat, cure, or
prevent any disease.
Description
Functions
Indications
Suggested Use
Side Effects/Warnings
Storage
References:
Each tablet
contains:
Copper (bis-glycinate)
2 mg*
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