<A HREF="http://www.thegreenpharmacy.com" TITLE="The Green Pharmacy"><IMG SRC="https://store.nexternal.com/greenpharm/Logo-9thvector_Nexternal.jpg" ALT="The Green Pharmacy" NAME="The Green Pharmacy" BORDER=0></A><BR> <H1>Copper 2 mg 100 caps -- The Green Pharmacy Shopping Cart</H1> <B>$4.70</B> -- <I>Amino Acid Chelate</I> <P> <IMG SRC="https://store.nexternal.com/greenpharm/images/DL_Copper_2_mg.jpg" ALIGN=right ALT="Copper 2 mg 100 caps" NAME="Copper 2 mg 100 caps" BORDER=0 HSPACE=10> <style> <!-- h5 { font-family: Arial; font-size: 12pt; color: #008000; font-weight: bold; border-bottom: 1px dotted #008000; margin-top: 12; margin-bottom: 0; padding: 1px } numbered list small { list-style-type: decimal; font-family: Arial; font-size: 8pt; text-align: left; line-height: 11pt; margin-left: 5; margin-top: 6; margin-bottom: 6 } body { font-family: Arial; font-size: 11pt } .body1 { font-family: Arial; font-size: 11pt; line-height: 14pt; margin-top: 4; margin-bottom: 8 } .body2 { font-family: Arial; font-size: 11pt; line-height: 14pt; margin-top: 8; margin-bottom: 4 } .table1 { font-family: Arial; font-size: 12pt; color: #008000; font-weight: bold; padding-top: 1px; padding-bottom: 1px } --> </style> <font FACE="Arial-Bold"><b> <h5 ALIGN="LEFT">Description</h5> </b></font><font FACE="Arial" SIZE="1"> <p ALIGN="LEFT" class="body1">Copper amino acid chelate, provided by Douglas Laboratories, is a patented, nutritionally functional bis-glycinate chelate (Albion Labs) with excellent bioavailability. Each tablet delivers 2 mg of elemental copper.</p> </font><b> <h5 ALIGN="LEFT">Functions</h5> </b><font FACE="Univers" SIZE="1"> <p ALIGN="LEFT" class="body1">Copper is an essential trace element and functions as a cofactor of many enzymes involved in antioxidant defense (superoxide dismutase), connective tissue metabolism (lysyl oxidase), and amine metabolism (amine oxidases). Superoxide dismutase (SOD) is a key antioxidant enzyme in the body&#8217;s cellular fluid (the cytosol) and mitochondria (the cell&#8217;s powerhouses). SOD destroys harmful superoxide anions that are either generated during normal energy metabolism or coming from environmental pollution. Cytosolic SOD activity is dependent on sufficient levels of copper and zinc. Many studies have shown that increasing dietary intake of these essential trace elements may increase the activity of SOD considerably. </p> <p ALIGN="LEFT" class="body1">As the essential cofactor of several amine oxidases, copper assumes a pivotal role in the metabolism and degradation of amines. Monoamine oxidase is involved in the inactivation of catecholamines. It reacts with substances such as serotonin, norepinephrine, tyramine, and dopamine. Diamine oxidase inactivates histamine and polyamines. Histamine is produced by the immune system during allergic reactions in response to antigens. Lysyl oxidase acts on the lysyl side chains of collagen and elastin, providing the basis for cross-link formation within connective tissues. </p> <p ALIGN="LEFT" class="body1">Copper is also important in many aspects of iron metabolism (ceruloplasmin, ferroxidase), mitochondrial energy and phospholipid metabolism (cytochrome c oxidase), and dopamine metabolism (dopamine &#226;- hydroxylase, tyrosinase). In the nervous system, copper is required for myelin formation and maintenance, as well as for normal neurotransmission. Absorption of free, ionic copper from foods is about 30- 40% efficient, and can be severely compromised by free zinc and some antagonistic ligands in food, such as phytate. Compared to free copper, the copper amino acid chelate is more bioavailable and less influenced by antagonistic factors. Several studies showed that the Albion chelate leads to excellent tissue retention of copper, as evidenced by effective stimulation of SOD activity.</p> </font><font FACE="Univers-Bold"><b> <h5 ALIGN="LEFT">Indications</h5> </b> <p ALIGN="LEFT" class="body1">Copper may be a useful nutritional adjunct for individuals who wish to increase their intake of copper.</p> <b> <h5 ALIGN="LEFT">Suggested Use</h5> </b> <p ALIGN="LEFT" class="body1">One tablet daily as a dietary supplement, or as directed by a physician. Take with food.</p> <b> <h5 ALIGN="LEFT">Side Effects/Warnings</h5> </b></font><font FACE="Univers" SIZE="1"> <p ALIGN="LEFT" class="body1">No adverse effects have been reported.</p><font FACE="Univers-Bold"><b> <h5 ALIGN="LEFT">Storage</h5> </b></font> <p ALIGN="LEFT" class="body1">Store in a cool, dry place, away from direct light.</p> <p ALIGN="LEFT" class="body1">Keep out of reach of children.</p> </font><font FACE="Univers-Bold"><b> <h5 ALIGN="LEFT">References:</h5> </b></font><font SIZE="1"> <ol> <li> <p ALIGN="LEFT">Danks DM. Copper deficiency in humans. Ann Rev Nutr 1988;8:235- 237. </li> <li> <p ALIGN="LEFT">Kivirikko KI, Peltonen L. Abnormalities in copper metabolism and disturbances in the synthesis of collagen and elastin. Med Biol 1982:60:45-48. </li> <li> <p ALIGN="LEFT">Klevay LM. Copper and ischemic heart disease. Biol Trace Elem Res 1983;5:245-255. </li> <li> <p ALIGN="LEFT">Klevay LM et al. Increased cholesterol in a young man during experimental copper depletion. Metabolism 1984;33:1112-1118. </li> <li> <p ALIGN="LEFT">Uauy R et al. Red cell superoxide dismutase activity as an index of human copper nutrition. J Nutr 1985;115:1650-1655.</li> </ol> <font face="Arial" size="2" color="#2A4591"> <b>Each tablet contains:</b><table width="351" cellpadding="0" cellpadding="0"> <tr> <td width="270" background="/images/dots2.gif" nowrap> <font size="2" color="#2A4591">Copper (bis-glycinate)</font></td><td width="75" background="/images/dots2.gif" align="right" nowrap> <font size="2" color="#2A4591">2 mg*</font></td></tr> </table></font></font> <font face="Arial" color="#2A4591"> <p>*These statements have not been evaluated by the Food and Drug Administration. 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