
Glucosamine Sulfate, provided by Douglas
Laboratories, is a well-absorbed source of glucosamine, an important precursor
for the synthesis and maintenance of connective tissues. Glucosamine is a naturally occurring amino sugar
found in glycosaminoglycans, integral components of the proteoglycans found in
joint cartilage. Proteoglycans are large carbohydrate rich structures that
provide resiliency, load distribution, shockabsorbing, compressive and
lubricating properties to joints and connective tissues. The availability of
glucosamine is an integral part of the synthesis of glycosaminoglycans and
proteoglycans that are necessary during the constant remodeling that aging
cartilage undergoes. Thus, the maintenance of healthy aging cartilage may be
improved with enhanced deposition of glycosaminoglycans and proteoglycans.
Dietary glucosamine serves as an immediate precursor for glycosaminoglycan
synthesis, and also stimulates incorporation of other precursors into the
connective tissue matrix. Bioavailability of oral glucosamine sulfate is
excellent. It is absorbed intact, and utilized very quickly by all tissues,
including connective tissues. Glucosamine sulfate is more efficiently used for
connective tissue metabolism than other glucosamine sources, such as cartilage
extracts or chondroitin sulfate. In summary, glucosamine sulfate is a well
recognized, highly effective source of glucosamine for glycosaminoglycan and
proteoglycan synthesis in all connective tissues, such as cartilage, ligaments,
tendons, skin, and bone. Glucosamine Sulfate capsules may be a useful
dietary supplement for individuals who wish to support the structure and
function of the body’s connective tissues, such as cartilage, bone, tendons,
ligaments, and skin. Adults take 1 capsule daily or as directed by
physician. No adverse effects have been reported. Store in a cool, dry place, away from direct
light. Keep out of reach of children. Anonymous. [Gonarthrosis--current aspects of therapy with
glucosamine sulfate (dona200-S)]. Fortschr Med Suppl 1998;183:1-12. Giordano, N, Nardi, P, Senesi, M, Palumbo, F, Battisti, E,
Gonnelli, S, Franci, B, Campagna, MS, Gennari, C. [The efficacy and safety
of glucosamine sulfate in the treatment of gonarthritis]. Clin Ter
1996;147:99-105. Gottlieb, MS. Conservative management of spinal
osteoarthritis with glucosamine sulfate and chiropractic treatment. J
Manipulative Physiol Ther 1997;20:400-14. Leffler, CT, Philippi, AF, Leffler, SG, Mosure, JC, Kim, PD.
Glucosamine, chondroitin, and manganese ascorbate for degenerative joint
disease of the knee or low back: a randomized, double-blind,
placebo-controlled pilot study. Mil Med 1999;164:85-91. Lopes Vaz, A. Double-blind clinical evaluation of the
relative efficacy of ibuprofen and glucosamine sulphate in the management of
osteoarthrosis of the knee in out-patients. Curr Med Res Opin 1982;8:145-9.
McCarty, MF. The neglect of glucosamine as a treatment for
osteoarthritis-- a personal perspective. Med Hypotheses 1994;42:323-7.
Qiu, GX, Gao, SN, Giacovelli, G, Rovati, L, Setnikar, I.
Efficacy andsafety of glucosamine sulfate versus ibuprofen in patients with
knee osteoarthritis. Arzneimittelforschung 1998;48:469-74. Russell, AL. Glucosamine in osteoarthritis and
gastrointestinal disorders: an exemplar of the need for a paradigm shift.
Med Hypotheses 1998;51:347-9. Setnikar, I, Pacini, MA, Revel, L. Antiarthritic effects of
glucosamine sulfate studied in animal models. Arzneimittelforschung
1991;41:542-5. Tapadinhas, MJ, Rivera, IC, Bignamini, AA. Oral glucosamine
sulphate in the management of arthrosis: report on a multi-centre open
investigation in Portugal. Pharmatherapeutica 1982;3:157-68. *These statements have not been evaluated by the Food and Drug
Administration. This product is not intended to diagnose, treat, cure, or
prevent any disease.
Description
Functions
Indications
Suggested Use
Side Effects/Warnings
Storage
References:
Each Capsule
Contains:
Glucosamine Sulfate
500 mg
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