
FlavonAll®, provided by Douglas Laboratories®, is
a convenient dietary multi-flavonoid supplement designed to provide a broad
spectrum of beneficial antioxidant flavonoids in nutritionally meaningful
amounts. FlavonAll delivers these flavonoids in the form of eight potent
standardized extracts that are of the highest quality available. Flavonoids are a class of phytochemicals that are
responsible for many of the brilliant colors of fruits and vegetables. They are
perhaps the most beneficial phytochemicals found in food. Flavonoids are
extremely potent antioxidants, scavenging many potentially damaging free
radicals. Some flavonoids appear to be much more potent antioxidants than even
beta-carotene, vitamin C or vitamin E. Many flavonoids are also capable of
binding to metal ions, which prevents these metals from acting as catalysts that
enhance free radical production in the body. Many flavonoids support the health
of the body’s circulatory system by helping maintain proper vascular
permeability, integrity, and resiliency. Flavonoids also have a wide array of
other biochemical functions. For example, flavonoids are involved in immune
function, gene expression, capillary and cerebral blood flow, platelet
aggregation, liver function, enzyme activity, and collagen, phospholipid,
cholesterol, and histamine metabolism. Pycnogenol and Grape Seed Extract. Pine
bark extract (Pycnogenol®) and grape seed extract are rich in proanthocyanidins,
which are highly regarded for their strong antioxidant properties and their role
in supporting the body’s connective tissues and capillary blood vessel system.
FlavonAll provides the original pine bark extract from the European coastal pine
(Pinus maritima) containing 80 to 85% proanthocyanidins. A high-quality European
grape seed extract (from Vitis vinifera) with a minimum of 92% proanthocyanidins
is also included. Typical maintenance amounts of pine bark or grape seed extract
are about 0.5 milligram per pound body weight per day. Accordingly, FlavonAll
provides 75 mg of a combination of both extracts in a suggested daily intake of
two tablets. Red Grape Skin Extract. The skins of red and black grapes are rich
in the dark red-violet flavonoids, the anthocyanins that are also present in red
wine. Studies show that these flavonoids are surprisingly strong antioxidants.
They are many times more potent than vitamin E, helping prevent the detrimental
oxidation of blood lipoproteins. FlavonAll contains 100 mg of a concentrated
extract made from the skins of Spanish red grapes providing a minimum of 30%
anthocyanins. Bilberry Extract. Bilberries (Vaccinium myrtillus), a northern
European cousin of the North American blueberries, are a rich source of
anthocyanosides. Aside from being potent antioxidants, bilberry anthocyanosides
were found to be important for eye health, capillary stability and blood flow,
healthy veins, and normal wound healing. For maintenance purposes, two tablets
of FlavonAll contain 120 mg of a standardized 25% anthocyanoside extract made
from ripe Swedish bilberries. Green Tea Extract. Green tea (Camellia sinensis)
is one of the most widely consumed beverages in the world. Chinese and Japanese
people typically consume 2 to 10 cups of green tea daily providing polyphenolic
catechins, such as catechin, epi-catechin, epi-gallocatechin (EGC), and EGC
gallate (EGCG). Twenty times stronger than vitamin E, EGC and EGCG play
important roles in the body’s defense against free radicals. Green tea catechins
also support normal immune response, and are involved in blood cholesterol
metabolism. To realize the full benefits of green tea, two tablets of FlavonAll
provide 900 mg of a top quality decaffeinated green tea extract with 20%
polyphenols. In terms of catechins, each tablet of FlavonAll is equivalent to
one cup of freshly brewed green tea. Ginkgo Biloba Extract. Known in traditional
Chinese folklore for about 5,000 years, the leaves of the Ginkgo biloba tree
provide flavonoids as flavone glycosides and terpene lactones, which are
important non-flavonoid phytochemicals. Numerous studies have evaluated the
influence of ginkgo terpene lactones on capillary and cerebral microcirculation.
Research also shows that the abundant flavone glycosides in ginkgo are potent
antioxidants. The total benefit of ginkgo is most probably based on the
synergistic effects of its constituents. Gingko extract is respected for its
potency and purity, and is derived only from young, fresh leaves that are
especially rich in flavone glycosides and terpene lactones. The many human
trials performed with ginkgo have used 120 mg per day of the 50:1 standardized
extract. About 80 mg per day is more appropriate for maintenance purposes and is
the amount provided by two tablets of FlavonAll. FlavonAll’s Ginkgo extract
(50:1) delivers a guaranteed minimum potency of 24% flavone glycosides and 6%
terpene lactones. It also provides a minimum of 0.8% ginkgolide B. Milk Thistle
Extract. Milk thistle (Silybum marianum) is a Mediterranean plant producing
fruits that are rich in a group of flavonoids, known collectively as silymarin.
Silymarin has been shown to support healthy liver function under a variety of
environmental stress factors such as alcohol consumption and exposure to
pollutants and other potentially harmful substances. Silymarin compounds are
also known for their antioxidant activities preventing lipid peroxidation by
excessive free radical levels. FlavonAll delivers 175 mg of a top quality
standardized European milk thistle extract with a guaranteed minimum potency of
80% or 140 mg of silymarin in two tablets. Citrus Bioflavonoids. The white
albedo layer of citrus peels is especially rich in the bitter tasting flavanones
hesperidin and naringin. Citrus juices, however, are low in bioflavonoids. Like
most flavonoids, those from citrus are free radical scavenging antioxidants that
work in synergy with vitamin C. FlavonAll provides 250 mg of a concentrated
complex containing 50% citrus bioflavonoids, of which 75% is hesperidin and 25%
naringin. This extract is essentially free of citric acid to which some people
may be sensitive. FlavonAll may be taken as a dietary supplement for
individuals who wish to increase their intake of a broad spectrum of
nutritionally important flavonoids. One to two tablets, two times daily as a dietary
supplement, or as directed by physician. No adverse effects have been reported. Store in a cool, dry place, away from direct
light. Keep out of reach of children. Bu-Abbas A et al. Marked antimutagenic potential of aqueous
green tea extracts: mechanism of action. Mutagenesis 1994;9:325-331. Ferenci P et al. Randomized controlled trial of silymarin
treatment in patients with cirrhosis of the liver. J Hepatol 1989;9:105-113.
Fitzpatrick DF et al. Endothelium-dependent vasorelaxing
activity of wine and other grape products. Am J Physiol 1993;265:H774-H778.
Gao YT et al. Reduced risk of esophageal cancer associated
with green tea consumption. J Natl Cancer Inst 1994;86:855-858. Kanner et al. Natural antioxidants in grapes and wines. J
Agric Food Chem 1994;42:64-69. Klaunig JE. Chemopreventive effects of green tea components
on hepatic carcinogenesis. Prev Med 1992;21:510-519. Lietti A et al. Studies on Vaccinium myrtillus
anthocyanosides I. Vasoprotective and antiinflammatory activity. Arzneim
Forsch 1976;26:829-832. Magistretti MJ et al. Antiulcer activity of an anthocyanidin
from Vaccinium myrtillus. Arnzneim Forsch 1988;38:686-690. Mukhtar H et al. Green tea and skin--anticarcinogenic
effects. J Invest Dermatol 1994;102:3-7. Nakayama M et al. Inhibition of the infectivity of influenza
virus by tea polyphenols. Antiviral Res 1993;21:289-299. Robert AM et al. Action of anthocyanosides of Vaccinium
myrtillis on the permeability of the blood brain barrier. J Med
1977;8:321-332. Robert L et al: Action of procyanidolic oligomers on
vascular permeability. Path Biol 1990;38:608-616. Uchida S. et al. Radioprotective effects of (-)-epigallocatechin
3-o-gallate (green tea tannin) in mice. Life Sci 1992;50:147-152. Wang ZY et al. Antimutagenic activity of green tea
polyphenols. Mutation Res 1989;223:273-285. *These statements have not been evaluated by the Food and Drug
Administration. This product is not intended to diagnose, treat, cure, or
prevent any disease.
Description
Functions
Indications
Suggested Use
Side Effects/Warnings
Storage
References:
Two tablets contain:
Pycnogenol®* Pine Bark Extract**
(min. 85%
proanthocyanidins)
10 mg
Grape Seed Extract** (min. 92%
proanthocyanidins)
65 mg
Red Grape Skin Extract (min. 30% anthocyanins)
100 mg
Bilberry Extract (min. 25% anthocyanosides)
120 mg
Green Tea Extract (decaffeinated, 20%
polyphenols)
900 mg
Ginkgo Biloba Extract (min. 24% ginkgo
80 mg
flavone glycosides,
min. 6% terpene lactones)
Milk Thistle Extract (min. 80% silymarin)
175 mg
Citrus Bioflavonoid Complex (min. 50%
bioflavonoids)
250 mg
*Pycnogenol is a trademark of Horphag
Research Ltd., U.K.
**Protected by U.S. patent #4,698,360 and
other international patents.
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