<A HREF="http://www.thegreenpharmacy.com" TITLE="The Green Pharmacy"><IMG SRC="https://store.nexternal.com/greenpharm/Logo-9thvector_Nexternal.jpg" ALT="The Green Pharmacy" NAME="The Green Pharmacy" BORDER=0></A><BR> <H1>l-Carnosine -- The Green Pharmacy Shopping Cart</H1> <B>$46.95</B> -- <I>Antioxidant dipeptide for cell protection</I> <P> <IMG SRC="https://store.nexternal.com/greenpharm/images/PE_l_Carnosine.jpg" ALIGN=right ALT="l-Carnosine" NAME="l-Carnosine" BORDER=0 HSPACE=10> <style> <!-- h5 { font-family: Arial; font-size: 12pt; color: #008000; font-weight: bold; border-bottom: 1px dotted #008000; margin-top: 12; margin-bottom: 0; padding: 1px } numbered list small { list-style-type: decimal; font-family: Arial; font-size: 8pt; text-align: left; line-height: 11pt; margin-left: 5; margin-top: 6; margin-bottom: 6 } body { font-family: Arial; font-size: 11pt } .body1 { font-family: Arial; font-size: 11pt; line-height: 14pt; margin-top: 4; margin-bottom: 8 } .body2 { font-family: Arial; font-size: 11pt; line-height: 14pt; margin-top: 8; margin-bottom: 4 } .table1 { font-family: Arial; font-size: 12pt; color: #008000; font-weight: bold; padding-top: 1px; padding-bottom: 1px } --> </style> <font FACE="Arial-Bold"><b> <h5 ALIGN="LEFT">What Is It?</h5> </b></font><font FACE="Arial" SIZE="1"> <p ALIGN="LEFT" class="body1">l-Carnosine (beta-alanyl-L-histidine) occurs naturally in the body's muscle and nervous tissues and is formed by the amino acids alanine and histidine. Levels of this dipeptide can decline with age. The primary context of support for l-carnosine involves cellular longevity support.*</p> </font><b><font FACE="Univers-Bold"> <h5 ALIGN="LEFT">Uses For l-Carnosine</font></h5> </b><font FACE="Univers" SIZE="1"> <p ALIGN="LEFT" class="body1"><b>Antioxidant Support:</b> l-Carnosine is a water-soluble antioxidant with well-documented free-radical scavenging activity and is believed to promote cell health and cell longevity. In vitro experiments show carnosine to be a potent scavenger of peroxyl and hydroxyl radicals. Carnosine may also help to maintain superoxide dismutase (SOD) activity. SOD is an important antioxidant enzyme.* </p> <p ALIGN="LEFT" class="body1"><b>Cellular Support:</b> In vitro, it helps to protect proteins from the formation of advanced glycosylation end-products. These end-products are formed when aldehydes (such as aldose and ketose sugars) and lipid peroxidation by-products bind to vital proteins and compromise their function. l-Carnosine also plays a role in protecting DNA from the effects of acetaldehyde and formaldehyde.* </p> <p ALIGN="LEFT" class="body1"><b>Nervous System Support:</b> l-Carnosine may help to maintain healthy peptide metabolism in the brain, supporting neuronal cell health.* </p> <p ALIGN="LEFT" class="body1"><b>Cardiovascular Support:</b> Its membrane-stabilizing properties maintain healthy lactate dehydrogenase activity of cardiovascular cells, providing a protective effect.* </p> <p ALIGN="LEFT" class="body1"><b>Muscular Support:</b> The concentration of l-carnosine in muscle may prove to be an important factor in high-intensity exercise performance based on a recent human study.* Liver Support: A preliminary animal study shows carnosine has the potential to support healthy liver function.*</p> </font><font FACE="Univers-Bold"><b> <h5 ALIGN="LEFT">What Is The Source?</h5> </b></font><font FACE="Univers" SIZE="1"> <p ALIGN="LEFT" class="body1">l-Carnosine is synthetically produced.</p> </font><font FACE="Univers-Bold"><b> <h5 ALIGN="LEFT">Recommendations</h5> </b></font><font FACE="Univers" SIZE="1"> <p ALIGN="LEFT" class="body1">Pure Encapsulations recommends between 500-1500 mg daily (1-3 capsules), in divided doses, between meals.</p> </font><font FACE="Univers-Bold"><b> <h5 ALIGN="LEFT">Are There Any Potential Side Effects Or Precautions?</h5> </b></font><font FACE="Univers" SIZE="1"> <p ALIGN="LEFT" class="body1">Not to be taken by pregnant or lactating women. At this time, there are no known side effects or precautions.</p> </font><font FACE="Univers-Bold"><b> <h5 ALIGN="LEFT">Are There Any Potential Drug Interactions?</h5> </b></font><font FACE="Univers" SIZE="1"> <p ALIGN="LEFT" class="body1">In animal studies, carnosine has been shown to inhibit intestinal uptake of several antibiotics. This has not been shown in humans, but it might be wise for those taking antibiotics to make sure they don't take carnosine at the same time.</p> </font><font FACE="Univers-Bold"><b> <h5 ALIGN="LEFT">References:</h5> </b></font><font SIZE="1"> <ol> <li> <p ALIGN="LEFT">Kang JH, Kim KS, Choi SY, Kwon HY, Won MH, Kang TC. Carnosine and related dipeptides protect human ceruloplasmin against peroxyl radicalmediated modification. Mol Cells2002 Jun 30;13(3) 498-502. </p></li> <li> <p ALIGN="LEFT">Hipkiss AR, Preston JE, Himsworth DT, Worthington VC, Keown M, Michaelis J, Lawrence J, Mateen A, Allende L, Eagles PA, Abbott NJ. Pluripotent protective effects of carnosine, a naturally occurring dipeptide. Ann N Y Acad Sci1998 Nov 20;854:37-53. </p></li> <li> <p ALIGN="LEFT">Prokop'eva VD, Laptev BI, Afanas'ev SA. The protective effect of carnosine in hypoxia and reoxygenation of the isolated rat heart. Biokhimiia1992 Sep;57(9):1389-92.</p></li> <li> <p ALIGN="LEFT">Preston JE, Hipkiss AR, Himsworth DT, Romero IA, Abbott JN. Toxic effects of beta-amyloid(25-35) on immortalised rat brain endothelial cell: protection by carnosine, homocarnosine and beta-alanine. Neurosci Lett 1998 Feb 13;242(2):105-8. </p></li> <li> <p ALIGN="LEFT">McFarland GA, Holliday R. Further evidence for the rejuvenating effects of the dipeptide L-carnosine on cultured human diploid fibroblasts. Exp Gerontol 1999 Jan;34(1):35-45. </p></li> <li> <p ALIGN="LEFT">Hipkiss AR, Michaelis J, Syrris P. Non-enzymatic glycosylation of the dipeptide L-carnosine, a potential anti-protein-cross-linking agent. FEBS Lett1995 Aug 28;371(1):81-5. </p> </li> <li> <p ALIGN="LEFT">Brownson C, Hipkiss AR. Carnosine reacts with a glycated protein. Free Radic Biol Med2000 May 15;28(10):1564-70. </p></li> <li> <p ALIGN="LEFT">Hipkiss AR, Brownson C, Carrier MJ. Carnosine, the anti-ageing, anti-oxidant dipeptide, may react with protein carbonyl groups. Mech Ageing Dev 2001 Sep 15;122(13):1431-45. </p></li> <li> <p ALIGN="LEFT">Suzuki Y, Ito O, Mukai N, Takahashi H, Takamatsu K. High Level of Skeletal Muscle Carnosine Contributes to the Latter Half of Exercise Performance during 30-s Maximal Cycle Ergometer Sprinting. Jpn J Physiol2002 Apr;52(2):199-205. </p></li> <li> <p ALIGN="LEFT">Tabakman R, Lazarovici P, Kohen R. Neuroprotective effects of carnosine and homocarnosine on pheochromocytoma PC12 cells exposed to ischemia. J Neurosci Res2002 May 15;68(4):463-9. </p></li> <li> <p ALIGN="LEFT">Hipkiss AR, Brownson C, Bertani MF, Ruiz E, Ferro A. Reaction of carnosine with aged proteins: another protective process? Ann N Y Acad Sci2002 Apr;959:285-94. </p></li> <li> <p ALIGN="LEFT">Healthnotes Clinical Essentials. Copyright 2004. Healthnotes, Inc.</p></li> </ol> <font face="Arial" size="2" color="#2A4591"> <b>each vegetable capsule contains:</b><table width="375" cellpadding="0" cellpadding="0"> <tr><td width="300" background="/images/dots2.gif" nowrap> <font size="2" color="#2A4591">l-carnosine (beta-alanyl-L- histidine)</font></td><td width="75" background="/images/dots2.gif" align="right" nowrap> <font size="2" color="#2A4591">500 mg.</font></td></tr> </table></font></font> <p><font size="2" color="#2A4591">Not to be taken by pregnant or lactating women. </font> </p> <p><font size="2" color="#2A4591">1&#8211;3 capsules per day, in divided doses, between meals. </font> </p> </P> <P><B>Other products in the category <A HREF="http://www.nexternal.com/greenpharm/Category44" TITLE="Categories">Categories</A> / <A HREF="http://www.nexternal.com/greenpharm/Category35" TITLE="Antioxidants">Antioxidants</A>:</B> <BR clear=left><BR><A HREF=http://www.nexternal.com/greenpharm/Product658 TITLE="A/O Maximizers&#174; 60 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