
l-Carnosine (beta-alanyl-L-histidine) occurs
naturally in the body's muscle and nervous tissues and is formed by the amino
acids alanine and histidine. Levels of this dipeptide can decline with age. The
primary context of support for l-carnosine involves cellular longevity support.* Antioxidant Support: l-Carnosine is a
water-soluble antioxidant with well-documented free-radical scavenging activity
and is believed to promote cell health and cell longevity. In vitro experiments
show carnosine to be a potent scavenger of peroxyl and hydroxyl radicals.
Carnosine may also help to maintain superoxide dismutase (SOD) activity. SOD is
an important antioxidant enzyme.* Cellular Support: In vitro, it helps to
protect proteins from the formation of advanced glycosylation end-products.
These end-products are formed when aldehydes (such as aldose and ketose sugars)
and lipid peroxidation by-products bind to vital proteins and compromise their
function. l-Carnosine also plays a role in protecting DNA from the effects of
acetaldehyde and formaldehyde.* Nervous System Support: l-Carnosine may
help to maintain healthy peptide metabolism in the brain, supporting neuronal
cell health.* Cardiovascular Support: Its
membrane-stabilizing properties maintain healthy lactate dehydrogenase activity
of cardiovascular cells, providing a protective effect.* Muscular Support: The concentration of l-carnosine
in muscle may prove to be an important factor in high-intensity exercise
performance based on a recent human study.* Liver Support: A preliminary animal
study shows carnosine has the potential to support healthy liver function.* l-Carnosine is synthetically produced. Pure Encapsulations recommends between 500-1500 mg
daily (1-3 capsules), in divided doses, between meals. Not to be taken by pregnant or lactating women. At
this time, there are no known side effects or precautions. In animal studies, carnosine has been shown to
inhibit intestinal uptake of several antibiotics. This has not been shown in
humans, but it might be wise for those taking antibiotics to make sure they
don't take carnosine at the same time. Kang JH, Kim KS, Choi SY, Kwon HY, Won MH, Kang TC.
Carnosine and related dipeptides protect human ceruloplasmin against peroxyl
radicalmediated modification. Mol Cells2002 Jun 30;13(3) 498-502. Hipkiss AR, Preston JE, Himsworth DT, Worthington VC, Keown
M, Michaelis J, Lawrence J, Mateen A, Allende L, Eagles PA, Abbott NJ.
Pluripotent protective effects of carnosine, a naturally occurring dipeptide.
Ann N Y Acad Sci1998 Nov 20;854:37-53. Prokop'eva VD, Laptev BI, Afanas'ev SA. The protective
effect of carnosine in hypoxia and reoxygenation of the isolated rat heart.
Biokhimiia1992 Sep;57(9):1389-92. Preston JE, Hipkiss AR, Himsworth DT, Romero IA, Abbott JN.
Toxic effects of beta-amyloid(25-35) on immortalised rat brain endothelial
cell: protection by carnosine, homocarnosine and beta-alanine. Neurosci Lett
1998 Feb 13;242(2):105-8. McFarland GA, Holliday R. Further evidence for the
rejuvenating effects of the dipeptide L-carnosine on cultured human diploid
fibroblasts. Exp Gerontol 1999 Jan;34(1):35-45. Hipkiss AR, Michaelis J, Syrris P. Non-enzymatic
glycosylation of the dipeptide L-carnosine, a potential
anti-protein-cross-linking agent. FEBS Lett1995 Aug 28;371(1):81-5. Brownson C, Hipkiss AR. Carnosine reacts with a glycated
protein. Free Radic Biol Med2000 May 15;28(10):1564-70. Hipkiss AR, Brownson C, Carrier MJ. Carnosine, the
anti-ageing, anti-oxidant dipeptide, may react with protein carbonyl groups.
Mech Ageing Dev 2001 Sep 15;122(13):1431-45. Suzuki Y, Ito O, Mukai N, Takahashi H, Takamatsu K. High
Level of Skeletal Muscle Carnosine Contributes to the Latter Half of
Exercise Performance during 30-s Maximal Cycle Ergometer Sprinting. Jpn J
Physiol2002 Apr;52(2):199-205. Tabakman R, Lazarovici P, Kohen R. Neuroprotective effects
of carnosine and homocarnosine on pheochromocytoma PC12 cells exposed to
ischemia. J Neurosci Res2002 May 15;68(4):463-9. Hipkiss AR, Brownson C, Bertani MF, Ruiz E, Ferro A.
Reaction of carnosine with aged proteins: another protective process? Ann N
Y Acad Sci2002 Apr;959:285-94. Healthnotes Clinical Essentials. Copyright 2004. Healthnotes,
Inc.
What Is It?
Uses For l-Carnosine
What Is The Source?
Recommendations
Are There Any Potential Side Effects Or Precautions?
Are There Any Potential Drug Interactions?
References:
each vegetable capsule contains:
l-carnosine (beta-alanyl-L- histidine)
500 mg.
Not to be taken by pregnant or lactating women.
1–3 capsules per day, in divided doses, between meals.
Other products in the category Categories / Antioxidants:
A/O Maximizers® 60 tabs -- Broad-Spectrum Antioxidant Supplement
Acai 100 32 fl oz
Acai 600 180 caps
Acai 600 90 caps
Acerola/Flavonoid -- A vitamin C formula with the additional protective action of bioflavonoids
Acetyl-L-Carnitine 500 mg -- Neuroprotection from a Potent Carnitine Metabolite
Adrenal - Support 1 oz -- Helps supply energy and replenish the adrenals
Alpha-Lipoic Acid 100 mg 60 tabs -- The Universal Antioxidant with Metabolic Functions
Annatto Tocotrienol 60ct -- This tocotrienols formula is a unique tocopherols-FREE, tocotrienols only product extracted from food grade annatto from the South American annatto bean.
Anti-Alcohol Antioxidants with HepatoProtection Complex, 100 caps
Anti-Oxidant 60 caps
Anti-oxidant 90 caps -- Wide spectrum antioxidant protection
AntiOxidant Formula 120 vcaps -- Protection against free radicals
Aqua Gem-E 400 IU 60 gels
ArthroSoothe 120 caps -- Powerful joint support nutraceutical compounds
Ascorbic Acid (vitamin C), 16 oz powder
Ascorbyl Palmitate -- Fat-soluble vitamin C
Ascorbyl Palmitate 500 mg, 100 caps
Ascorbyl Palmitate Powder 100 gms.
Astaxanthin -- Powerful antioxidant for the skin, macula, joints, immune system and cardiovascular function
Basic Antioxidant 100 tabs -- Provides antioxidant support
Blueberry Extract, 60 vcaps
Cardio-Edge™ 120 vcaps -- Sytrinol™, Plant Sterols and Pomegranate extract for cardiovascular and cholesterol health
CocoaGold™ Cocoa Polyphenols, 60 vegetarian caps
Coenzyme Q-10 with Lipoic Acid -- Lipoic Acid (Thioctic Acid) protects against damage to the cells caused by oxidative stress and free radicals.
Coffee Granate Forte 60 caps -- A Unique Combination of Standardized Pomegranate Fruit and Coffee Fruit Extracts
C-Plex™ Powder 240 gms -- Buffered Vitamin C Plus Bioflavonoids
DHLA Nano-Plex -- Unparalleled Anti-Aging & Energy Boosting
E-Mulsion 200 -- Emulsified vitamin E
EpiCor™ 30 capsules -- An all-natural, high-metabolite immunogen that nourishes the body’s immune system
EpiCor™ 90 capsules -- An all-natural, high-metabolite immunogen that nourishes the body’s immune system
EpiCor™ Junior -- An all-natural, high-metabolite immunogen that nourishes the body’s immune system
FlavonAll® 60 tabs -- Broad-Spectrum Multi-Flavonoid Supplement
FruiTEA-Max™ 700 mg 60 vcaps -- Potent antioxidant combination of white tea, pomegranate, apple and blueberry extracts
Gamma E Tocopherol with Sesame Lignans -- Suppress damaging free radicals
Glutathione Plus™ 60 caps -- Glutathione Plus N-Acetylcysteine
Grape Seed Extract with Resveratrol -- Pure oligomeric proanthocyanidins with resveratrol
Grape Seed Extract-V 100 mg 30 caps -- Antioxidants
Grapenol® 50 mg 90 tabs -- A Full-Spectrum Grape Extract with Resveratrol
Green Tea Extract -- Possesses significant thermogenic properties. As an antioxidant, green tea extract has been shown to be 20 times stronger than vitamin E.
GSH 250™ 90 caps -- Specially formulated to potentiate antioxidant protection
Hesperidin Methyl Chalcone 500 mg 60 caps -- A Methylated Form of the Flavonoid Hesperidin
High ORAC Synbiotic Formula -- Therapeutic foods that help you heal
IsoProtein Plus® French Vanilla 575 grams -- Convenient source of nutrition for daily wellness. In Original, French Vanilla and Strawberry Banana Creme flavors.
IsoProtein Plus® -Original 550 grams -- Convenient source of nutrition for daily wellness. In Original, French Vanilla and Strawberry Banana Creme flavors.
IsoProtein Plus® Strawberry Banana Creme 559 grams -- Convenient source of nutrition for daily wellness. In Original, French Vanilla and Strawberry Banana Creme flavors.
L-Carnosine 500 mg 30 caps -- Antioxidants, Energy/Sports/Fitness
L-Cystine 500 mg 60 caps -- Antioxidants
L-Glutathione 250 mg -- Antioxidants, Stress Control/Relaxants
Life Extension Booster 60 softgels