EstroFlavone™ 60 caps (Categories / Female Health) -- The Green Pharmacy Shopping Cart -- caps 60 EstroFlavone™

<A HREF="http://www.thegreenpharmacy.com" TITLE="The Green Pharmacy"><IMG SRC="https://store.nexternal.com/greenpharm/Logo-9thvector_Nexternal.jpg" ALT="The Green Pharmacy" NAME="The Green Pharmacy" BORDER=0></A> <H1>EstroFlavone™ 60 caps -- The Green Pharmacy Shopping Cart</H1> $27.95 -- Comprehensive Nutritional Support During Menopause <IMG SRC="https://store.nexternal.com/greenpharm/images/DL_EstroFlavone.jpg" ALIGN=right ALT="EstroFlavone™ 60 caps" NAME="EstroFlavone™ 60 caps" BORDER=0 HSPACE=10> <style>  </style> <h5 ALIGN="LEFT">Description</h5> EstroFlavone™ capsules, provided by Douglas Laboratories®, contain hesperidin methyl chalcone, concentrated soy isoflavones, and black cohosh root and rhizome extract, standardized to contain a minimum of 2.5% triterpenes. <h5 ALIGN="LEFT">Functions</h5> Hesperidin Methyl Chalcone: Hesperidin methyl chalcone is a methylated derivative of the flavonoid hesperidin. Hesperidin methylchalcone supports and  protects the integrity of the vascular system with particular activity in the capillaries and veins. Hesperidin methylchalcone has been shown to help strengthen capillaries by increasing capillary resistance and decreasing capillary permeability. Increased venous motility, tone, and the ability of vessels to dilate are also enhanced by hesperidin methylchalcone. Soy Isoflavone Concentrate: Isoflavones are a class of phytoestrogens — plant-derived compounds that are similar in structure and/or function to animal estrogens. In plants, isoflavones are bound to glycosides. During digestion, colonic bacteria are thought to metabolize the inactive isoflavone glycosides into their active counterparts. Soybeans and soy products are the most well-known and significant dietary sources of isoflavones. Genistein and daidzein, two of the predominant isoflavones that are beneficial to health, are present in significant concentrations in soy foods. Epidemiological studies have found that individuals with high soy intakes often enjoy certain health advantages. Numerous laboratory and clinical studies have investigated the health benefits of soy, many of  which have identified soy isoflavones as key components responsible for the health benefits associated with soy foods. Isoflavones have both weak estrogenic and antiestrogenic activity, which may contribute to their ability  to moderate menopausal symptoms and support maintenance of bone mineral density. Isoflavones also help protect the cardiovascular system, support the immune system, inhibit angiogenesis, and protect against oxidative damage as antioxidants. Black Cohosh: Black cohosh extract is quickly gaining popularity as a natural way to moderate and balance hormone levels. The active constituents of black cohosh appear to regulate estrogen levels, thereby normalizing hormonal balance and moderating the symptoms that accompany fluctuating hormone levels. Black cohosh extract works largely through the synergistic activity of two types of compounds: phytoestrogens and triterpenes. Phytoestrogens, a class of flavonoids with mild estrogenic activity in the body, appear to have normalizing effects on hormonal levels. In particular, black cohosh extract contains formononetin, an isoflavone phytoestrogen. Triterpene glycosides found in black cohosh extract act synergistically with formononetin to suppress excessive secretion of luteinizing hormone (LH). Sudden increases in LH secretion, which occur in response to declining estrogen levels, appear largely responsible for many symptoms associated with menopause, such as hot flashes, night sweats, insomnia, irritability, heart palpitations, and headaches. Additionally, the concerted activity of formononetin and triterpenes appears to aid in the regulation of estrogen balance. As with other estrogenic compounds, the active constituents in black cohosh extract may have beneficial effects in the cardiovascular and skeletal systems of postmenopausal women. As such, black cohosh offers a safe and natural method of balancing fluctuating hormone levels and easing the resulting symptoms that can occur during menopause. <h5 ALIGN="LEFT">Indications</h5> EstroFlavone™ may be a beneficial component of the nutritional support program of women who wish to assist hormone balance and support the health of blood vessels and capillaries during menopause. <h5 ALIGN="LEFT">Suggested Use</h5> 1 to 2 capsules daily with meals or as directed by physician. It is recommended that prolonged use of black cohosh beyond six months be under physician supervision. <h5 ALIGN="LEFT">Side Effects/Warnings</h5> No adverse effects have been reported. <h5 ALIGN="LEFT">Storage</h5> Store in a cool, dry place, away from direct light. Keep out of reach of children. <h5 ALIGN="LEFT">References:</h5> <ol> <li> Adlercreutz H, Mousavi Y, Clark J, et al. Dietary phytoestrogens and cancer: in vitro and in vivo studies. J Steroid biochem Mol Biol 1992;41:331-7. </li> <li> Akiyama T, Ishida J, Nakagawa S, et al. Genistein, a specific inhibitor of tyrosine-specific protein kinases. J Biol Chem 1987;262:5592-5. </li> <li> Baird DD, Umbach DM, Lansdell L, et al. Dietary intervention study to assess estrogenicity of dietary soy among postmenopausal women. J Clin Endocrinol Metab 1995;80:1685-90. </li> <li> Barnes S, Peterson TG. Biochemical targets of the isoflavone genistein in tumor cell lines. Proc Soc Exp Biol Med 1995;208:103-8. </li> <li> Beuscher, N. Cimicifuga racemosa L.- Black Cohosh. Quarterly Review of Natural Medicine Spring 1996. </li> <li> Beaugerie L, Luboinski J, Brousse N, et al. Drug induced lymphocyctic colitis. Gut 1994;35(3):426-8. </li> <li> Bouskela E, Cyrino FZGA, Marcelon G, et al. Inhibitory effect of the Ruscus Extract and of the flavonoid hesperidin methylchalcone on increased microvascular permeability. J Cardiovasc Pharmacol 1993;22:225-230. </li> <li> Chanal JL Cousse H, Sicart MT, et al. Absorption and elimination of carbon-14 labeled hesperidin methyl chalcone in the rat. Eur J Drug Metab Pharmacokinet 1981;6:171-178. </li> <li> Cluzan RV, Alliot F, Ghabboun S, et al. Treatment of secondary lymphedema of the upper limb with CYCLO 3 FORT. Lymphology 1996;29:29-35. </li> <li> Constantinou A, Huberman E. Genistein as an inducer of tumor cell differentiation: possible mechanisms of action. Proc Soc Exp Biol Med 1995;208:109-15. </li> <li> Coope J. Hormonal and non-hormonal interventions for menopausal symptoms. Maturitas 1996;23:159-68. </li> <li> Domange JR, Bougaret S, Yubero L. Pharmacological studies of Cyclo 3 Fort and its constituents (Ruscus extract, hesperidin methyl chalcone, ascorbic acid): An up to date review. Clinical Hemorheology 1994;14:S7-S13. </li> <li> Duker EM, Kopanski L, Jarry H, Wuttke E. Effects of extracts from Cimicifuga racemosa on gonadotropin release in menopausal women and ovarectomized rats. Planta Medica 1991;57:420-4. </li> <li> Gooderham MH, Adlercreutz H, Ojala ST, et al. A soy protein isolate rich in genistein and daidzein and its effects on plasma isoflavone concentration, platelet aggregation, blood lipids and fatty acid composition of plasma phospholipid in normal men. J Nutr 1996;126:2000-6. </li> <li> Hodgson JM, Puddey IB, Beilin LJ, et al. Supplementation with isoflavonoid phytoestrogens does not alter serum lipid concentrations: a randomized controlled trial in humans. J Nutr 1998;128:728-32. </li> <li> Hsieh CY, Snatell RC, Haslam SZ, Helferich WG. Estrogenic effects of genistein on the growth of estrogen receptof-positive human breast cancer (MCF-7) cells in vitro and in vivo. Cancer Res 1998;58:3833-8. </li> <li> Ingram, D, Sanders, K, Kolybaba, M, et. al. Case-control study of phytoestrogens and breast cancer. Lancet 1997;350:990-994. </li> <li> Kawabe M, Tamano S, Shibata MA, et al. Subchronic toxicity study of methyl hesperidin in mice. Toxicol Lett 1993 Jul;69(1):37-44. </li> <li> Knight DC, Eden JA. A review of the clinical effects of phytoestrogens. Obstet Gynecol 1996;87:897-904. </li> <li> Kurata Y, Fukushima S, Hagiwara A, et al. Carcinogenicity study of methyl hesperidin in B6C3F1 mice. Food Chem Toxicol 1990 Sep;28(9):613-8. </li> <li> Lieberman S. A review of the effectiveness of Cimicifuga racemosa (black cohosh) for the symptoms of menopause. Journal of Womens Health 1998;7:525- 9. </li> <li> Lock M. Menopause: lessons from anthropology. Psychosomatic Medicine 1998;60:410-9. </li> <li> Nagata C, Takatsuka N, Kurisu Y, Shimizu H. Decreased serum total cholesterol concentration is associated with high intake of soy products in Japanese men and women. J Nutr 1998;128:209-213. </li> <li> Rudofsky G. [Improving venous tone and capillary sealing. Effect of a combination of Ruscus extract and herperidine methyl chalcone in healthy probands in heat stress]. Fortschr Med 1989;107:55-8. </li> <li> Ruiz-Larrea MB, Mohan AR, Paganga G, et al. Antioxidant activity of phytoestrogenic isoflavones. Free Radic Res 1997;26:63-70. </li> <li> Svensjo E, Bouskela E, Cyrino FZ, Bougaret S. Antipermeability effects of Cyclo 3 Fort in hamsters with moderate diabetes. Clin Hemorheol Microcirc 1997;17(5):385-8. </li> <li> Thomas-Anterion C, Guy C, Vial F, et al. [Unexplained chronic diarrhea, apropos of 4 new cases under Cyclo 3 Fort and review of literature]. Rev Med Interne 1993;14(4):215-7. </li> <li> Wang C, Kurzer MS. Phytoestrogen concentration determines effect on DNA synthesis in human breast cancer cells. Nutr Cancer 1997;28:236-47. </li> <li> Xu X, Duncan AM, Merz BE, Kurzer MS. Effects of soy isoflavones on estrogen and phytoestrogen metabolism in premenopausal women. Cancer Epidemiol Biomarkers Prev 1998;7:1101-8. </li> <li> Yamaguchi M, Gao YH. Inhibitory effect of genistein on bone resorption in tissue culture. Biochem Pharmacol 1998;55:71-6. </li> <li> Zava DT, Duwe G. Estrogenic and antiproliferative properties of genistein and other flavonoids in human breast cancer cells in vitro. Nutr Cancer 1997;27:31- 40. </li> <li> Zheng, QY. A novel botanical extract for menopausal women. Madis Botanicals, Inc. 1997. </li> </ol> Each capsule contains:<table width="351" cellpadding="0" cellpadding="0"> <tr> <td width="270" background="/images/dots2.gif" nowrap> Hesperidin Methyl Chalcone</td><td width="75" background="/images/dots2.gif" align="right" nowrap> 250 mg</td></tr> <tr> <td width="270" background="/images/dots2.gif" nowrap> Soy Isoflavone Concentrate (NovaSoy®,</td><td width="75" background="/images/dots2.gif" align="right" nowrap>  </td></tr> <tr> <td width="270" background="/images/dots2.gif" nowrap> min. 40% isoflavones)</td><td width="75" background="/images/dots2.gif" align="right" nowrap> 100 mg</td></tr> <tr> <td width="270" background="/images/dots2.gif" nowrap> Black Cohosh (Cimicifuga racemosa)</td><td width="75" background="/images/dots2.gif" align="right" nowrap>  </td></tr> <tr> <td width="270" background="/images/dots2.gif" nowrap> Root and rhizome, dried extract, min. 2.5%</td><td width="75" background="/images/dots2.gif" align="right" nowrap>  </td></tr> <tr> <td width="270" background="/images/dots2.gif" nowrap> Terpenes</td><td width="75" background="/images/dots2.gif" align="right" nowrap> 40 mg</td></tr> </table> *These statements have not been evaluated by the Food and Drug Administration. 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