
Amino-Iron™, provided by Douglas Laboratories®, is
a patented, nutritionally functional iron amino acid chelate (iron bis-glycinate)
with documented high bioavailability, excellent tolerability, and low toxicity.
Each 18 mg tablet of Amino-Iron supplies 100% of the daily requirement (US RDA)
of iron for adults and children 4 or more years of age. Iron accomplishes its major function of oxygen
transport as a component of two different transport molecules: hemoglobin in red
blood cells and myoglobin in muscle. As a cofactor for a large number of enzymes
and enzyme systems, iron is essential for energy metabolism. Iron is the
cofactor of most of the enzymes of the Krebs cycle, and it is an electron
carrier in the cytochromes. Healthy subjects with adequate iron status absorb
between 5 and 10 % of dietary iron from foods. Iron absorption is regulated by
the body, increasing during iron deficiency. Dietary factors also influence iron
absorption efficiency. For example, ascorbic acid (vitamin C) increases and
phytic acid (found in whole grains) decreases its absorption. Most of the
absorbed iron is used for hemoglobin synthesis. Excess iron is stored as
ferritin in liver, spleen, bone marrow and other organs. The body has a limited
capacity to excrete iron. With advancing age, iron often accumulates in tissues.
Excessive amounts of unbound iron can act as a catalyst of free radical damage
and membrane lipid peroxidation, leading to a variety of degenerative,
pathologic changes. Men over the age of 30 and post-menopausal women have a
tendency to accumulate iron in tissues. Thus, once iron stores have been
replenished, iron supplementation should be discontinued, unless bleeding or
other causes of iron loss are present. Iron excretion occurs in feces, skin, and
urine. Many menstruating women excrete significant amounts of iron through
normal menstrual blood losses. Pregnancy and lactation increase iron
requirements two- or three-fold. Adequate amounts of iron are also needed to
support growth, especially during growth spurts, e.g., during early infancy or
during the growth spurt of adolescent males. Iron deficiency occurs in three
stages. In the first stage of iron depletion, iron stores are diminished, as
reflected in low plasma ferritin levels, but no functional impairment is
present. The second stage is characterized by close to normal red cell
hemoglobin although its production is already impaired. Work capacity may be
impaired. In the third stage of iron deficiency anemia, total blood hemoglobin
levels are below normal, and red cells appear small and pale. Iron deficiency
anemia is associated with low work capacity (tiredness), apathy, irritability,
reduced physical performance and decreased immune function. Amino-Iron is
efficiently absorbed and utilized by the body. Studies have shown that the iron
bis-glycinate of Amino-Iron has a very low toxicity when compared with
conventional iron salts. Amino-Iron may be a useful nutritional adjunct for
individuals who wish to increase their intake of iron. One tablet daily as a dietary supplement, or as
directed by physician. Take with food. No adverse effects have been reported. Store in a cool, dry place, away from direct
light. Keep out of reach of children. Ashmead HD: Conversations on Chelation and Mineral
Nutrition. Keats Publishing, Inc., New Canaan, CT,1989. Finch C, Cook JD: Iron Deficiency. Am J Clin Nutr
1982;39:471-477. Guttridge JM, Rowley DA, Halliwell B: Superoxide-dependent
formation of hydroxyl radicals and lipid peroxidation in the presence of
iron salts. Biochem J 1982;206:605-609. Hallberg L: Bioavailability of dietary iron in man. Ann Rev
Nutr 1981;1:123-147. Hallberg L, Rossander-Hulten L: Iron requirements in
menstruating women. Am J Clin Nutr 1991;54:1047-1058. Pineda O, Ashmead HD, Perez JM, Lemus CP: Effectiveness of
iron amino acid chelate on the treatment of iron deficiency anemia in
adolescents. J Appl Nutr 1994;46:2-13. Viteri F, Torun B: Anemia and physical work capacity. Clin
Hematol 1974;3:609-612. *These statements have not been evaluated by the Food and Drug
Administration. This product is not intended to diagnose, treat, cure, or
prevent any disease.
Description
Functions
Indications
Suggested Use
Side Effects/Warnings
Storage
References:
Each tablet
contains:
Iron (bis-glycinate)
18 mg
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