
Ester-C® is a natural, non-acidic water-soluble
form of vitamin C that is distinguished by its unique chemical composition and
biological activity. It is manufactured in an exclusive, water-based process
that results in a mixture of naturally occurring vitamin C metabolites,
including ascorbate, dehydroascorbate, and threonate.* Antioxidant Support: Animal studies show
increased plasma vitamin C concentration and delayed urinary excretion with
administration of Ester-C, suggesting that it is readily absorbed and
efficiently utilized. Calcium l-threonate, a metabolite of calcium ascorbate,
may facilitate the transport and uptake of vitamin C, playing a key role in
optimizing cellular levels. A human study involving 12 subjects indicated
favorable bioavailability as well as revealing a boost in white blood cell
levels. The bioflavonoids quercetin, rutin and pomegranate extract are powerful
free radical scavengers that complement the roles of vitamin C. Quercetin helps
maintain healthy histamine release and moderates healthy leukotriene and
prostaglandin metabolism. Rutin and pomegranate extract provide important
support for blood vessel integrity and healthy cell function.* Ester-C® mineral ascorbates are manufactured from
ascorbic acid, mineral oxides and mineral carbonates. The mineral oxides and
carbonates are mined domestically. The ascorbic acid is derived from corn
fermentation. Quercetin and rutin are derived from the Brazilian botanicals
dimorphandra and the fava danta tree respectively. Pomegranate (punica granatum
l.) extract is standardized to contain 5% ellagic acid. Vitamin C (ascorbyl
palmitate) is derived from corn dextrose fermentation and palm oil. Ester-C® or
® is a licensed trademark of Zila Nutraceuticals, Inc. Manufactured under U.S.
Patent 4,822,816 and 5,070,085 and corresponding foreign patents; other patents
pending. Pure Encapsulations recommends 1 or more capsules
daily, with or between meals. If pregnant or lactating, consult your physician
before taking this product. People with the following conditions should consult
their doctor before supplementing with vitamin C: glucose-6-phosphate
dehydrogenase deficiency, iron overload (hemosiderosis or hemochromatosis),
history of kidney stones, or kidney failure. It has been suggested that people
who form calcium oxalate kidney stones should avoid vitamin C supplements
because vitamin C can convert into oxalate and increase urinary oxalate. In rare
cases, quercetin may cause headaches and mild tingling of the extremities.
Consult your physician for more information. Quercetin may react with calcium channel blockers,
estradiol, and immune suppressive drugs. Consult your physician for more
information. Van Straten M, Josling P. Preventing the common cold with a
vitamin C supplement: a double-blind, placebo-controlled survey. Adv Ther.
2002 May- Jun;19(3):151-9. Bush MJ, Verlangieri AJ. An acute study on the relative
gastro-intestinal absorption of a novel form of calcium ascorbate. Res
Commun Chem Pathol Pharmacol. 1987 Jul;57(1):137-40. Verlangieri AJ, Fay MJ, Bannon AW. Comparison of the
anti-scorbutic activity of L-ascorbic acid and Ester C in the non-ascorbate
synthesizing Osteogenic Disorder Shionogi (ODS) rat. Life Sci. 1991;48
23):2275-81. Fay MJ, Bush MJ, Verlangieri AJ. Effect of cytochalasin B on
the uptake of ascorbic acid and glucose by 3T3 fibroblasts: mechanism of
impaired ascorbate transport in diabetes. Life Sci. 1990;46(9):619- 4. Fay MJ, Verlangieri AJ. Stimulatory action of calcium L-threonate
on ascorbic acid uptake by a human T-lymphoma cell line. Life Sci.
1991;49(19):1377-81. Effect of aldonic acids on the uptake of ascorbic acid by
3T3 mouse fibroblasts and human T lymphoma cells. Fay MJ, Bush MJ,
Verlangieri AJ. Gen Pharmacol. 1994 Nov;25(7):1465-9. Healthnotes Clinical Essentials. Copyright 2005. Healthnotes,
Inc.
619 mg.
68 mg.
7 mg.
50 mg.
What Is It?
Uses For Ester-C & flavonoids
What Is The Source?
Recommendations
Are There Any Potential Side Effects Or Precautions?
Are There Any Potential Drug Interactions?
References:
each vegetable capsule contains:
calcium ascorbate blend
800 mg.
providing
(typical):
vitamin C (from calcium ascorbate)
calcium (from calcium ascorbate)
threonic acid
quercetin
rutin
50 mg.
pomegranate (punica granatum L.) extract (whole fruit)
50 mg.
(standardized to contain 5% ellagic acid)
2.5 mg.
vitamin C (ascorbyl palmitate)
10 mg.
1 or more capsules per day, with or between meals.
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