Cogni-flex™ 60 caps (Categories / Neurological / Neurological Support) -- The Green Pharmacy Shopping Cart -- caps 60 Cogni-flex™

<A HREF="http://www.thegreenpharmacy.com" TITLE="The Green Pharmacy"><IMG SRC="https://store.nexternal.com/greenpharm/Logo-9thvector_Nexternal.jpg" ALT="The Green Pharmacy" NAME="The Green Pharmacy" BORDER=0></A> <H1>Cogni-flex™ 60 caps -- The Green Pharmacy Shopping Cart</H1> $38.00 -- Nutritional support for healthy mental function <IMG SRC="https://store.nexternal.com/greenpharm/images/DL_Cogni_Flex.jpg" ALIGN=right ALT="Cogni-flex™ 60 caps" NAME="Cogni-flex™ 60 caps" BORDER=0 HSPACE=10> <style>  </style> <h5 ALIGN="LEFT">Description</h5> Cogni-flex™, provided by Douglas Laboratories, is a unique combination of nutrients and herbs (huperzine A, Ginkgo biloba, phosphatidyl serine, and acetyl-L carnitine) which work in concert to maintain and enhance brain and nervous system functions, including those involved in mental alertness,  clarity, and memory retention. These positive effects of the four components of Cogni-flex™ upon structure and function of the nervous system are supported by numerous scientific/clinical studies <h5 ALIGN="LEFT">Functions</h5> The four nutrients in Cogni-flex™ support the structure and function of cognitive processes in several ways. They support neurotransmitter metabolism, enhance vascular circulation to the brain, and help maintain structure and function of nerve cell membranes. Huperzine A: An extract of the Chinese club moss, Huperzia serrata, huperzine A has been used in Chinese medicine for centuries. It is an effective inhibitor of acetylcholinesterase, the enzyme that degrades acetylcholine, the neurotransmitter important for normal memory and learning function. Huperzine A may help maintain cognitive function that has been degraded by a reduction in the brain’s functional levels of the neurotransmitter acetylcholine. Ginkgo biloba: Flavonoid compounds and terpene lactones in the ginkgo leaf help regulate the structural tone and elasticity of arteries and capillaries. As powerful antioxidants, the ginkgo flavonoids counteract the deleterious actions of free radical accumulation which impairs functional cellular energy production and nerve transmission. Ginkgo biloba extract is also reported to inhibit the tendency of red blood cells to stick together (“clumping”), thereby enhancing the functional fluidity of the blood. Improving the functional circulation to the brain and other parts of the body allows for better oxygen and glucose uptake, with subsequent enhancement of memory and mental functions. Phosphatidylserine: This phospholipid, found in high concentrations in the nervous system, helps maintain functional fluidity of nerve cell membranes, thus providing for optimal transport of nutrients and other compounds across the cell membrane. It is also used in the repair and regeneration of nerve cells. Phosphatidylserine also appears to help the body counterbalance excessive release of adrenocorticotropic hormone (ACTH), adrenaline, and cortisol which are released in response to stress. Acetyl-L-carnitine: This acetylated high energy ester of the amino acid L-carnitine contributes its acetyl group to the production of acetylcholine, the primary neurotransmitter for memory and thought. The enzyme that makes acetylcholine from acetyl groups and choline is choline acetyl transferase. The activity of this important enzyme has a tendency to decline with age, causing low acetylcholine levels which in turn are thought to contribute to the impairment of brain function that is associated with aging. Research has also found that acetyl-L-carnitine is active in optimizing the functioning of cerebral blood flow, as well as of nerve cell membranes. <h5 ALIGN="LEFT">Indications</h5> Cogni-flex™ capsules may be a useful dietary supplement for those who wish to support the healthy functioning of their mental processes. <h5 ALIGN="LEFT">Suggested Use</h5> Adults take 1 capsule daily or as directed by physician. <h5 ALIGN="LEFT">Side Effects/Warnings</h5> No adverse side effects reported <h5 ALIGN="LEFT">Storage</h5> Store in a cool, dry place, away from direct light. Keep out of reach of children. <h5 ALIGN="LEFT">References:</h5> <ol> <li> Brooks JO, 3rd, Yesavage JA, Carta A, Bravi D. Acetyl L-carnitine slows decline in younger patients with Alzheimer's disease: a reanalysis of a double-blind, placebo-controlled study using the trilinear approach. Int Psychogeriatr 1998;10:193-203. </li> <li> Calvani M, Arrigoni-Martelli E. Attenuation by acetyl-L-carnitine of neurological damage and biochemical derangement following brain ischemia and reperfusion. Int J Tissue React 1999;21:1-6. </li> <li> Camps P, El Achab R, Gorbig DM, Morral J, Munoz-Torrero D, Badia A, Eladi Banos J, Vivas NM, Barril X, Orozco M, Luque FJ. Synthesis, in vitro pharmacology, and molecular modeling of very potent tacrinehuperzine A hybrids as acetylcholinesterase inhibitors of potential interest for the treatment of Alzheimer's disease. J Med Chem 1999;42:3227-42. </li> <li> Cheng DH, Tang XC. Comparative studies of huperzine A, E2020, and tacrine on behavior and cholinesterase activities. Pharmacol Biochem Behav 1998;60:377-86. </li> <li> Clostre F. [Ginkgo biloba extract (EGb 761). State of knowledge in the dawn of the year 2000]. Ann Pharm Fr 1999;57 Suppl 1:1S8-88. </li> <li> Furushiro M, Suzuki S, Shishido Y, Sakai M, Yamatoya H, Kudo S, Hashimoto S, Yokokura T. Effects of oral administration of soybean lecithin transphosphatidylated phosphatidylserine on impaired learning of passive avoidance in mice. Jpn J Pharmacol 1997;75:447-50. </li> <li> Gorini A, D'Angelo A, Villa RF. Action of L-acetylcarnitine on different cerebral mitochondrial populations from cerebral cortex. Neurochem Res 1998;23:1485-91. </li> <li> Hagen TM, Ingersoll RT, Wehr CM, Lykkesfeldt J, Vinarsky V, Bartholomew JC, Song MH, Ames BN. Acetyl-L-carnitine fed to old rats partially restores mitochondrial function and ambulatory activity. Proc Natl Acad Sci U S A 1998;95:9562-6. </li> <li> Hagen TM, Wehr CM, Ames BN. Mitochondrial decay in aging. Reversal through supplementation of acetyl-L-carnitine and N-tertbutyl- alpha-phenyl-nitrone. Ann N Y Acad Sci 1998;854:214-23. </li> <li> Itil TM, Eralp E, Ahmed I, Kunitz A, Itil KZ. The pharmacological effects of ginkgo biloba, a plant extract, on the brain of dementia patients in comparison with tacrine. Psychopharmacol Bull 1998;34:391-7. </li> <li> Kanowski S, Herrmann WM, Stephan K, Wierich W, Horr R. Proof of efficacy of the ginkgo biloba special extract EGb 761 in outpatients suffering from mild to moderate primary degenerative dementia of the Alzheimer type or multi-infarct dementia. Pharmacopsychiatry 1996;29:47-56. </li> <li> Khalsa DS. Integrated medicine and the prevention and reversal of memory loss. Altern Ther Health Med 1998;4:38-43. </li> <li> Kidd PM. A review of nutrients and botanicals in the integrative management of cognitive dysfunction. Altern Med Rev 1999;4:144-61. </li> <li> Paradies G, Petrosillo G, Gadaleta MN, Ruggiero FM. The effect of aging and acetyl-L-carnitine on the pyruvate transport and oxidation in rat heart mitochondria. FEBS Lett 1999;454:207-9. </li> <li> Patocka J. Huperzine A--an interesting anticholinesterase compound from the Chinese herbal medicine. Acta Medica 1998;41:155-7. </li> <li> Rigney U, Kimber S, Hindmarch I. The effects of acute doses of standardized Ginkgo biloba extract on memory and psychomotor performance in volunteers. Phytother Res 1999;13:408-15. </li> <li> Sakai M, Yamatoya H, Kudo S. Pharmacological effects of phosphatidylserine enzymatically synthesized from soybean lecithin on brain functions in rodents. J Nutr Sci Vitaminol (Tokyo) 1996;42:47- 54. </li> <li> Salvioli G, Neri M. L-acetylcarnitine treatment of mental decline in the elderly. Drugs Exp Clin Res 1994;20:169-76. </li> <li> Smith PF, Maclennan K, Darlington CL. The neuroprotective properties of the Ginkgo biloba leaf: a review of the possible relationship to platelet-activating factor (PAF). J Ethnopharmacol 1996;50:131- . </li> <li> Taglialatela G, Caprioli A, Giuliani A, Ghirardi O. Spatial memory and NGF levels in aged rats: natural variability and effects of acetyl-Lcarnitine treatment. Exp Gerontol 1996;31:577-87. </li> <li> Ved HS, Koenig ML, Dave JR, Doctor BP. Huperzine A, a potential therapeutic agent for dementia, reduces neuronal cell death caused by glutamate. Neuroreport 1997;8:963-8. </li> <li> Wang H, Tang XC. Anticholinesterase effects of huperzine A, E2020, and tacrine in rats. Chung Kuo Yao Li Hsueh Pao 1998;19:27-30. </li> <li> Winter JC. The effects of an extract of Ginkgo biloba, EGb 761, on cognitive behavior and longevity in the rat. Physiol Behav 1998;63:425-33. </li> <li> Xiao QX, Yang JW, Tang XC. Huperzine A protects rat pheochromocytoma cells against hydrogen peroxide-induced injury [In Process Citation]. Neurosci Lett 1999;275:73-6. </li> <li> Xiong ZQ, Tang XC. Effect of huperzine A, a novel acetylcholinesterase inhibitor, on radial maze performance in rats. Pharmacol Biochem Behav 1995;51:415-9. </li> <li> Xu SS, Gao ZX, Weng Z, Du ZM, Xu WA, Yang JS, Zhang ML, Tong ZH, Fang YS, Chai XS, et al. Efficacy of tablet huperzine-A on memory, cognition, and behavior in Alzheimer's disease. Chung Kuo Yao Li Hsueh Pao 1995;16:391-5. </li> <li> Ye JW, Cai JX, Wang LM, Tang XC. Improving effects of huperzine A on spatial working memory in aged monkeys and young adult monkeys with experimental cognitive impairment. J Pharmacol Exp Ther 1999;288:814-9.</li> </ol> Each Capsule Contains:<table width="351" cellpadding="0" cellpadding="0"> <tr> <td width="270" background="/images/dots2.gif" nowrap> Huperzine A</td><td width="75" background="/images/dots2.gif" align="right" nowrap> 100 mcg</td></tr> <tr> <td width="270" background="/images/dots2.gif" nowrap> Ginkgo biloba</td><td width="75" background="/images/dots2.gif" align="right" nowrap> 20 mg</td></tr> <tr> <td width="345" background="/images/dots2.gif" nowrap colspan="2">      (standardized to 24% ginkgoflavonglycosides</td></tr> <tr> <td width="270" background="/images/dots2.gif" nowrap>      and 6% terpene lactones)</td><td width="75" background="/images/dots2.gif" align="right" nowrap>  </td></tr> <tr> <td width="270" background="/images/dots2.gif" nowrap> Phosphatidylserine</td><td width="75" background="/images/dots2.gif" align="right" nowrap> 10 mg</td></tr> <tr> <td width="270" background="/images/dots2.gif" nowrap> Acetyl-L-Carnitine</td><td width="75" background="/images/dots2.gif" align="right" nowrap> 10 mg</td></tr> </table> *These statements have not been evaluated by the Food and Drug Administration. 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