
Glucosamine Sulfate
Pharmax LLC, 800mg, 90 capsules
Glucosamine is naturally present in the human body and contributes to the formation of proteoglycans, essential in normal cartilage. In osteoarthritis and joint damage caused by everyday wear and tear, articular cartilage degenerates and thins, reducing its ability to resist the forces of everyday activity. Research has shown that oral supplementation of proteoglycan precursors leads to articular cartilage repair. This results in significant reductions in pain and stiffness, better than or equal to ibuprofen (NSAID). There is also evidence that Glucosamine maintains an individual's joint space increasing function and flexibility.
Glucosamine works to stimulate joint function and repair. It is most effective in treating osteoarthritis, the most prevalent type of arthritis. A number of studies over the last 20 years have shown this. For example, a 1982 clinical study compared usage of the NSAID ibuprofen with glucosamine sulfate, for osteoarthritis of the knee. During the first two weeks, ibuprofen decreased pain faster, but by the fourth week the glucosamine group was well ahead in pain relief. The overall results showed 44% of the glucosamine group had pain relief compared to 15% for ibuprofen. Because glucosamine is not an anti-inflammatory drug, it takes longer to start working, but it works equally well.
Another 1982 open trial study with 252 doctors and 1,506 patients conducted in Portugal provided good clinical information on appropriate dosage and usage of glucosamine sulfate for osteoarthritis. For 50 days, patients took 500 mg of glucosamine sulfate three times a day. The results showed 95% of the patients benefited from the supplement, as it reduced their pain whether they were resting, standing, or exercising. This study also showed the effects of glucosamine on obese patients, however, they may require higher dosages to offset the joints' reaction to the stress from obesity. Those patients also taking diuretics or suffering from peptic ulcers were also studied regarding the effect of, and their tolerance to, glucosamine. The former might require higher dosages and the latter need to take glucosamine with food.
In a more recent 2000 study at the Assaf Harofeh Medical Center, in Ziffrin, 57 patients with osteoarthritis in the knee were treated randomly for four weeks with glucosamine sulfate intravenously combined with an 800 mg of chondroitin sulfate daily, or with a placebo. As in the 1982 study, a record was kept of their knee pain when at rest, standing, or moving. No reduction of symptoms occurred with the placebo group, but the glucosamine/chondroitin sulfate group showed much reduction of symptoms in all activity/nonactivity functions. This latter group also showed no negative reactions or any change in their blood tests. The study concluded that glucosamine sulfate is safe for long-term osteoarthritis treatment.
Glucosamine supplements can also aid in treating sports injuries, bursitis, food and respiratory allergies, asthma, osteoporosis, tendinitis, vaginitis, some skin problems, and candidiasis.
Description
* High potency glucosamine sulfate
* Most clinically-proven connective tissue support nutrient
* Appropriate for individuals with joint stiffness and inflexibility
* Appropriate for individuals with rheumatoid or arthritic conditions
Ingredients Per capsule
* Glucosamine sulfate 800mg
Non-active ingredients
Vegetable magnesium stearate. Capsule: cellulose & water.
Recommended intake
1 - 2 capsules per day with a meal or as professionally directed.
Keep out of reach of children.
Contra-indications.
None known if recommended intake is followed.
Additional Info
A high-concentration, glucosamine sulfate supplement to reflect the excellent recent clinical trial success of this substance in relieving joint pain and improving joint flexibility and movement.
Glucosamine functions by modifying the equilibrium between constructing new connective tissue and the breakdown of existing tissue. The process is not immediate and, as such, at least 8 weeks of supplementation are required before significant benefits will be observed in many individuals.
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