
Melatonin P.R.tablets, provided by Douglas
Laboratories, contain 3 mg of purest pharmaceutical grade melatonin, in a
prolonged-release, bisected tablet. Melatonin is a natural hormone nutrient that is
synthesized from the amino acid tryptophan by the pineal gland in the back of
the brain. Melatonin also occurs in small amounts in a variety of foods. In the
body, melatonin appears to regulate sleep/wake cycles, support normal immune
function, and protect cells from free radical damage. Most of the research on melatonin has focused on
its role in maintaining normal sleep/wake rhythms. The perception of daylight in
the eyes is a signal for the pineal gland to inhibit melatonin synthesis and
release. At night or in the dark, the body’s melatonin production rises. The
rise in plasma melatonin is thought to be responsible for bringing on sleep.
Nocturnal melatonin production is highest in children and begins to decline from
adolescence on until it is virtually absent in the elderly. Melatonin supports normal immune function by
helping maintain the activity of circulating natural killer cells. It also has
been found to function as an antagonist for stress-induced immunosuppression.
Melatonin is considered a potent antioxidant that
enters all body cells to help prevent free radical damage. In the brain,
melatonin is perhaps the most important physiological antioxidant. Due to its
lipid and watersoluble properties, it can freely cross the blood-brain barrier.
In vitro studies show that melatonin is more effective than glutathione in
scavenging toxic hydroxyl radicals, and also more efficient than vitamin E in
neutralizing peroxyl radicals which can induce DNA damage. Furthermore,
melatonin stimulates the main antioxidant enzyme of the brain, glutathione
peroxidase. Melatonin P.R. tablets may be a useful dietary
supplement for individuals wishing to supplement their diet with melatonin. Adults take 1 tablet 1 hour before bedtime as
directed by physician only. Warning: Not to be taken by individuals under the age of
18. If you are pregnant, nursing, taking any prescription medication (especially
hormone replacement therapy), or have an autoimmune or depressive disorder
consult a physician before using this product. Long-term use of melatonin has
not been studied. Use of this product could cause hypothermia. Do not use before
or while operating a motor vehicle or heavy machinery. Store in a cool, dry place, away from direct
light. Keep out of reach of children. Alvarez B, Dahlitz M, Vignau J, Parkes JD: The delayed sleep
phase syndrome: Clinical and investigative findings in 14 patients. J Neurol
Neurosurg Psychiatry 1992;55:665-670. Armstrong SM, Redman JR: Melatonin: A chronobiotic with
antiaging properties? Med Hypotheses 1991;34:300-309. Beck-Friis J, Kjellman BF, Aperia B et al: Serum melatonin
in relation to clinical variables in patients with major depressive disorder
and a hypothesis of a low melatonin syndrome. Acta Psychiatr Scand
1985;71:319-330. Bismar K, Morgensen L, Wetterberg L: Depressed melatonin
secretion in patients with nightmares due to beta-adrenoceptor blocking
drug. Acta Med Scand 1987;221:155-158. Dahlitz M, Alvarez B, Vignau J et al: Delayed sleep phase
syndrome response to melatonin. Lancet 1991;337:1121-1124. Lieberman HR: Behavior, sleep and melatonin. J Neural Transm
Suppl 1989;21:233-241. Lissoni P, Barni S, Cattaneo G et al: Clinical results with
the pineal hormone melatonin in advanced cancer resistant to standard
antitumor therapies. Oncology 1991;48:448-450. *These statements have not been evaluated by the Food and Drug
Administration. This product is not intended to diagnose, treat, cure, or
prevent any disease.
Description
Functions
Indications
Suggested Use
Side Effects/Warnings
Storage
References:
Each capsule
contains:
Melatonin
3 mg
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