
Chelated Magneisum, provided by Douglas
Laboratories, supplies 100 mg of elemental magnesium in the form magnesium amino
acid chelate. Magnesium plays an essential role in a wide range
of funda-mental cellular reactions. More than 300 enzymes require magnesium as a
cofactor. Complexed with ATP, the main carrier of metabolic energy in the body,
magnesium is essential for all biosynthetic processes, glycolysis, formation of
c-AMP, energy-dependent membrane transport, trans-mission of genetic code for
protein synthesis, and muscle function. Of the 20-30 grams of total body
magnesium, about 40% is located in muscle and other soft tissues, and the
remainder in bone. The concentration of intracellular magnesium is carefully
regulated, and its alterations can have profound effects on cardiac and skeletal
muscle physiology. Healthy people require about 4.5 mg of dietary magnesium per
kg body weight, or 280 mg for a 62 kg female and 350 mg for a 76 kg male. The
U.S. RDA is 400 mg/day. The efficiency of magnesium absorption is a function of
dietary intake. At very low intakes (less than 40 mg) 65-70% of dietary
magnesium is absorbed, whereas at high intakes (1,000 mg) less than 15% is
absorbed. Most people are expected to absorb about 30-60% at common levels of
dietary magnesium. Contrary to common belief, recent studies suggest that
magnesium absorption is not affected by calcium or vitamin D, and vice-versa.
The kidney plays a critical role in magnesium homeostasis. At average magnesium
intakes, the kidneys reabsorb about 95% of the filtered magnesium. Chelated magnesium may be a useful dietary
supplement for individuals who wish to increase their dietary intake of
magnesium. Adults take 1 tablet daily with meals or as
directed by physician. No adverse side effects reported. Store in a cool, dry place, away from direct
light. Keep out of reach of children. Abbott L, Nadler J, Rude RK. Magnesium deficiency in
alcoholism: Possible contribution to osteoporosis and cardiovascular disease
in alcoholics. Alcoholism (NY) 1994;18:1076-1082. Adaniya H, Hayami H, Hiraoka M, Sawanobori T. Effects of
magnesium on polymorphic ventricular tachycardias induced by aconitine. J
Cardiovasc Pharmacol 1994;24:721-729. Al-Ghamdi SMG, Cameron EC, Sutton RAL. Magnesium deficiency:
Pathophysiologic and clinical overview. Am J Kidney Dis 1994;24:737-752.
Dahle LO, Berg G, Hammar M, Hurtig M, Larsson L. The effect
of oral magnesium substitution on pregnancy-induced leg cramps. Am J Obstet
Gynecol 1995;173:175-180. Durlach J, Durlach V, Bac P, Rayssiguier Y, Bara M, Guiet-Bara
A. Magnesium and ageing. II. Clinical data: Aetiological mechanisms and
pathophysiological consequences of magnesium deficit in the elderly. Magnes
Res 1993;6:379-394. *These statements have not been evaluated by the Food and Drug
Administration. This product is not intended to diagnose, treat, cure, or
prevent any disease.
Description
Functions
Indications
Suggested Use
Side Effects/Warnings
Storage
References:
1 Tablet contains:
Magnesium
100 mg
(from 500 mg Magnesium amino acid chelate)
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