
Beta 1,3D Glucan
Vitamin Research Products, 100 mg, 60 capsules
Beta-1,3/1,6-glucan is a potent immune-system enhancer shown to protect against viruses, bacteria, fungi, parasites, and free radicals. Research indicates that beta-1,3/1,6-glucan can benefit diabetes, arthritis, bacterial infections, fungal diseases, candida, heart disease, viral conditions (including herpes), and a host of other immunity-impaired and autoimmune diseases. Abundant research also suggests that beta-1,3/1,6-glucan may inhibit carcinogenesis. Furthermore, this yeast-derived nutrient can protect against chemotherapy damage, ultraviolet radiation, and radiation from computer monitors.
Empowering Macrophages
VITAMIN RESEARCH PRODUCTS offers a special, small-particle form of beta-1,3/1,6-glucan easily absorbed by macrophages, which ingest and destroy harmful foreign invaders. University of Nevada, Reno, researchers have discovered that macrophages absorb a higher percentage of small beta-glucan particles compared to the globular, larger molecule beta glucan found in many supplements. Other researchers have noted that monocytes — white blood cell precursors to macrophages — have beta-glucan receptors.
Numerous researchers have investigated beta glucan’s ability to serve as nutritional fuel for macrophages. In mice, oral administration of beta-1,3- glucan improved the macrophages’ pathogen-digesting ability and increased production of interleukin-1, which plays an integral role in immunity.
In another study, oral administration of beta-1,3-glucan (80 mg/kg) to mice enhanced natural killer cell activity in the spleen. In vitro experiments investigating beta glucan’s effect on human white blood cells have yielded equally promising results.
Cancer-Fighting Potential
In numerous animal trials, beta glucans have halted cancer cell progression. In one in vitro study, beta-1,3-glucan enhanced the tumor-killing ability of powerful disease-destroying white blood cells called polymorphonuclear leukocytes to the point where almost 100% of the cancerous cells were destroyed. In mice with experimental cancer, beta-1,3-glucan administered intraperitoneally, intralesionally or intravenously significantly inhibited tumors and enhanced macrophage and T-cell activity.
Limited studies suggest beta glucan may be protective against cancer in humans as well. Physicians using beta-1,3/1,6-glucan in clinical practice have observed that it can protect against the damage seen in radiation treatment. One physician treated five breast cancer patients undergoing radiation therapy with one capsule of beta-,3/1,6-glucan three times daily, while three breast cancer patients chose not to consume beta glucan. The patients supplemented with beta glucan did not suffer from radiation injury to the skin, whereas the three unsupplemented patients all showed signs of extensive radiation damage. United States Armed Forces scientists are another group of researchers who have discovered that beta glucan can protect against radiation damage.
Antibacterial, Antiviral Agent
Beta-1,3/1,6-glucan’s ability to boost immunity implies that this substance is an important nutritional weapon in the war against bacteria and viruses.
In one prospective, randomized, double-blind study, researchers demonstrated that the perioperative administration of beta glucan enhanced the activity of leukocytes, and was able to decrease infections in patients undergoing major surgical procedures. In multitrauma patients, beta-glucan reduced the incidence of hospital pneumonia from 55% to 9.5% and sepsis from 35% to 9.5%, decreasing the amount of time spent in intensive care and the hospital. In mice, beta-1,3-glucan derivatives have protected against otherwise lethal bacterial infections by reducing E. coli bacterial counts to zero. Furthermore, beta-glucan has killed the particularly dangerous bacteria, Staphylococcus aureus.
Beta glucan also has inhibited herpes simplex virus-1 by interfering with the way the virus interacts with cell plasma membranes. The ability to stimulate natural killer cells suggests that beta glucan can act as a potent antiviral agent.
Additional Benefits
Research has investigated beta glucan’s multi-faceted potential. In rats, beta- 1,3/1,6-glucan has dramatically decreased the incidence of diabetes from 43.3% to 6.7%. In other studies, this powerful nutrient has eliminated candida albicans; alleviated the symptoms of chronic fatigue syndrome; and increased the survival rate and improved immunity in mice with viral hepatitis. Furthermore, macrophages recognize arterial plaque as foreign invaders. Therefore, beta glucan’s macrophageenhancing ability suggests this nutrient may play a cardioprotective role.
As a maintenance dose, one capsule daily between meals. As a therapeutic dose, one capsule twice daily between meals. For those with compromised immune systems (from radiation treatments or bacterial, fungal, viral or parasitic invasions), 10 to 40 milligrams daily may be required.
Supplement Facts
Serving Size:1 Capsule
Amount Per Serving
Beta-1, 3-D Glucan (saccharomyces cerevisiae) 100mg
Residues of Carbohydrate*
Terminal glucose 3.6
1,3 linked glucose 86.6
1,6 linked glucose 2.1
2,3 linked glucose 5.8
3,6 linked glucose 1.9
* Typical analysis
Other Ingredients:
Microcrystalline cellulose and Hydroxypropyl methylcellulose (Vcap).
Contains no added starch, salt, wheat, gluten,
corn, coloring, or dairy products.
Keep container tightly closed in a cool,
dry and dark place. Keep out of reach of children.
REFERENCES
1. Donzis BA. Sustantially purified beta (1,3) finely ground yeast cell wall glucan composition with dermatological and nutritional uses. U.S. Patent 5576015, 1996.
2. Carrow DJ. Beta-1,3-glucan as a primary immune activator. Townsend Letter. June 1996.
3. Suzuki I, Tanaka H, Kinoshita A, Oikawa S, Osawa M, Yadomae T. Effect of orally administered beta-glucan on macrophage function in mice. Int J Immunopharmacol. 1990; 12(6):675-84.
4. Suzuki I, Hashimoto K, Ohno N, Tanaka H, Yadomae T. Immunomodulation by orally administered beta-glucan in mice. Int J Immunopharmacol. 1989; 11(7):761-9.
5. Abel G, Czop JK. Stimulation of human monocyte beta-glucan receptors by glucan particles induces production of TNF-alpha and IL-1 beta. Int J Immunopharmacolol. 1992; 14:1363-73.
6. Morikawa K, Takeda R, Yamazaki M, Mizuno D. Induction of tumoricidal activity of polymorphonuclear leukocytes by a linear beta-1,3-D-glucan and other immunomodulators in murine cells. Cancer Res. 1985; 45(4):1496-501.
7. Suzuki I, Hashimoto K, Yadomae T. The effects of a highly branched beta-1,3- glucan, SSG, obtained from Sclerotinia sclerotiorum IFO 9395 on the growth of syngeneic tumors in mice. J Pharmacobiodyn. 1988; 11(8):527-32.
8. Maurici da Rocha e Silva, et al. Infection prevention in patients with severe multiple trauma with the immunomodulater Beta 1-3 Polyglucose (glucan). Surgery, Gynecology & Obstetrics. 1993; 177:383-88.
9. Rasmussen LT, Seljelid R. Novel immunomodulators with pronounced in vivo effects
caused by stimulation of cytokine release. J Cell Biochem. 1991; 46(1):60-8.
10.Marchetti M, Pisani S, Pietropaolo V, Seganti L, Nicoletti R, et al. Antiviral effect
of a polysaccharide from Schlerotium glucanicum towards herpes simplex virus
type 1 infection. Planta Med. 1996; 62(4):301-7.
11.Kida K, Inoue T, et al. An immunopotentiator of beta-1,6,1,3D-glucan prevents
diabetes and insulitis in BB rats. Diabetes. Res Clin Pract. 1992; 17:75-79.
12.Williams DL, DiLuzio NR. Glucan-induced modification of murine viral hepatitis.
Science. 1980; 208:67-69.
13.Patchen ML, Brook I, Elliott TB, Jackson WE. Adverse effects of pefloxacin in
irradiated C3H/HeN mice: correction with glucan therapy. Antimicrob Agents
Chemotherapy. Dept. of Experimental Hematology, Armed Forces Radiobiology
Research Institute (AFRRI), Bethesda, Maryland, Sept. 1993.
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