
Grapenol® tablets, provided by Douglas
Laboratories®, contain 100% pure, full-spectrum grape extract. Each 50 mg scored
tablet is formulated to disintegrate rapidly within several minutes after
ingestion for maximum bioavailability. This highly concentrated red grape extract (Vitis
vinifera) is specially prepared to retain the natural antioxidant and biological
activity of various nutritional compounds occurring in the grape seeds, skin,
and stems. Using the whole grape, not just the seeds, yields a broader array of
antioxidant benefits, including those of resveratrol, a powerful free radical
fighter. Proanthocyanidins (also called leukoanthocyanidins)
are a class of natural polyphenolic bioflavonoids that are very widespread in
nature. They are found in many herbs, fruits and vegetables, and often are the
main precursors of the blue-violet and red pigments. More than 90% of the
proanthocyanidins in Grapenol occur as chains of two, three or more
proanthocyanidin molecules, which are called oligomeric proanthocyanidins (OPC).
These OPC are considered most potent for their health benefits. Only a small
fraction of Grapenol proanthocyanidins are present as single molecules
(monomers, like catechin and epi-catechin). Proanthocyanidins are highly regarded for their
strong antioxidant properties, and for their functions in supporting the body’s
connective tissues and capillary blood vessel system. Europeans have been studying and using various
forms of these natural proanthocyanidins for several decades for their numerous
beneficial effects. Proanthocyanidins are among the most powerful natural
free-radical scavengers yet discovered. As such, proanthocyanidins have their
own unique place in the body’s overall protection against harmful free radical
damage. Proanthocyanidins appear to be especially effective in neutralizing
highly reactive hydroxyl and singlet oxygen radicals. Both of these reactive
oxygen species are involved in the regulation of normal inflammatory processes.
Grapenol enhances the effectiveness of vitamins C and E and can be taken
together with these vitamins for added benefit. Proanthocyanidins also support and enhance the
activity of vitamin C, and are known for their ability to help support the
health of the body's capillary system and connective tissues. Proanthocyanidins
have been shown to bind with collagen fibers, thereby protecting them from
premature degradation. This helps maintain the natural elasticity of collagen in
skin, joints, arteries, capillaries, and other connective tissues. In addition to proanthocyanidins, Grapenol also
contains gallic acid and gallic acid esters, compounds that are known for their
astringent and antioxidant (gallic acid esters) properties. Grapenol tablets may be a useful nutritional
adjunct for individuals who wish to increase their intake of natural
antioxidants in the bioflavonoid family of nutrients. Grapenol can be helpful in
extending the benefits of vitamin C and other dietary antioxidants.
Bioflavonoids are unable to be synthesized in the body and must be obtained
through dietary intake. The flavonoids in Grapenol are readily available and
well-absorbed substances. The amount of Grapenol usually taken is based on
body weight as larger individuals can use more. Initial amounts for the first 7
to 10 days range from 1.5 to 3.0 milligrams per kilogram (2.2 pounds) of body
weight, followed by maintenance amounts of 50 to 100 mg per day (1 or 2 tablets)
to replace what is lost daily. The following general guidelines are based on
these parameters: Weight
7-10 days
Maintenance 100 lbs 100 mg (75 -
150) 50 mg 125 lbs 125 mg (100
- 175) 75 mg 150 lbs 150 mg (100
- 200) 75 mg 175 lbs 175 mg (125
- 225) 100 mg 200 lbs 200 mg (150
-250) 100 mg No adverse effects have been reported. Store in a cool, dry place, away from direct
light. Keep out of reach of children. Blazso G and Gabor M: Oedema-inhibiting effect of
procyanidin. Acta Physiologica Scientariium Hungaricae, Tomus 1980;56
(2):235-40. Cahn J, Borzeix MG.: "Etude de L'administration D'oligomeres
procyanidoliques (OPC) chez le rat." Extrait de La Semaine des Hospitaux de
Paris . 1983;59:27-28:2031-4. Gendre PMJ, Laparra J, and Barraud E: Effet protecteur des
oligomeres procyanidoliques sur le lathyrisme experimental chez le rat. Ann
Pharmaceutics Francaises 1985;43:61-71. Masquelier, Jacques, Plant extract with a proanthocyanidins
content as therapeutic agent having radical scavenging effect and use
thereof. U.S. Patent No. 4,698,360. Masquelier J, Dumon MC, and Dumas J: Stabilisation du
collagen par des oligomeres procyanidoliques. Acta Therapeutica
1981;7:101-5. Robert L et al: Action of procyanidolic oligomers on
vascular permeability. Path Biol 1990;38:608-616. Schwitters B: OPC in practice: Bioflavanols and their
application. Alfa Omega Publishers, Rome, 1993. Uchida et al: Condensed tannins scavenge active oxygen free
radicals. Med Sci Res 1987;15:831-832. Yu CL and Swaminathan B: Mutagenicity of proanthocyanidins.
Food Chem Toxicol 1987;25 (2):135-9. *These statements have not been evaluated by the Food and Drug
Administration. This product is not intended to diagnose, treat, cure, or
prevent any disease.
Description
Functions
Indications
Suggested Use
Side Effects/Warnings
Storage
References:
Each scored tablet
contains:
Grapenol® (full spectrum grape extract)
50 mg
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