
B12 Folic™ is a combination of two water-soluble B
vitamins, folic acid and vitamin B12. These two vitamins are interrelated in
function. They convert carbohydrates into energy and are vital in the metabolism
of fats and protein. They play an important role in the maintenance of muscle
tone in the GI tract, the functioning of the nervous system, and the integrity
of skin, hair, and the liver. Folic acid is essential for normal fetal neural
development. The B12 in this formula is provided as methylcobalamin, the most
bioavailable form of this vitamin, as it does not require intrinsic factor for
absorption. Healthy Fetal Neural Development: Folic acid is an
integral factor involved in the formation of nucleic acids and the production of
healthy DNA and chromosomes. In particular, this B vitamin is critical for the
proper neural and cellular development of the fetal central nervous system.
Folic acid promotes healthy cellular differentiation during the formation of the
brain and spinal cord, helping to prevent neural tube defects. Additionally,
folic acid is important for the growth and reproduction of red and white blood
cells. Nervous System Health: In recent studies,
methylcobalamin has demonstrated an enhanced ability to support neurological
function. Vitamin B12 promotes protein synthesis for maintaining healthy nerve
cells and myelin. Methylcobalamin may also help to moderate levels of glutamate
in the brain, encouraging healthy brain cell activity, as well as memory, mood,
and cognitive function. In general, vitamin B12 works with folate to promote DNA
and red blood cell health. Folic acid is synthetically produced.
Methylcobalamin is produced from corn dextrose fermentation. Hypo-allergenic
plant fiber is derived from pine cellulose. Vitamin C (ascorbyl palmitate) is
derived from corn dextrose fermentation and palm oil. Pure Encapsulations recommends 1-2 capsules per
day, in divided doses with meals. At this time, there are no known side effects or
precautions. If pregnant or lactating, consult your physician before taking this
product. Folic acid may adversely interact with
chemotherapeutic drugs. Quinlivan EP, McPartlin J, McNulty H, Ward M, Strain JJ,
Weir DG, Scott JM. Importance of both folic acid and vitamin B12 in
reduction of risk of vascular disease. Lancet 2002 Jan 19;359(9302):227-8. MRC Vitamin Study Research Group. Prevention of neural tube
defects: results of the Medical Research Council Vitamin Study. Lancet 1991
Jul 20;338(8760):131-137. Bower C, Stanley FJ. Dietary folate as a risk factor for
neural-tube defects: evidence from a case-control study in Western
Australia. Med J Aust 1989 Jun 5;150(11):613-619. Morrison HI, Schaubel D, Desmeules M, Wigle DT. Serum folate
and risk of fatal coronary heart disease. JAMA 1996 Jun
26;275(24):1893-1896. Shimizu N, Hamazoe R, Kanayama H, Maeta M, Koga S.
Experimental study of antitumor effect of methyl-B12. Oncology
1987;44(3):169-73. Weinberg JB, Shugars DC, Sherman PA, Sauls DL, Fyfe JA.
Cobalamin inhibition of HIV-1 integrase and integration of HIV-1 DNA into
cellular DNA. Biochem Biophys Res Commun 1998 May 19;246(2) 393-7. Akaike A, Tamura Y, Sato Y, Yokota T. Protective effects of
a vitamin B12 analog, methylcobalamin, against glutamate cytotoxicity in
cultured cortical neurons. Eur J Pharmacol 1993 Sep 7;241(1):1-6. Waikakul W, Waikakul S. Methylcobalamin as an adjuvant
medication in conservative treatment of lumbar spinal stenosis. J Med Assoc
Thai 2000 Aug;83(8):825-3. Mayer G, Kroger M, Meier-Ewert K. Effects of vitamin B12 on
performance and circadian rhythm in normal subjects. Neuropsychopharmacology
1996 Nov;15(5):456-64. Healthnotes Clinical Essentials. Copyright 2004. Healthnotes,
Inc.
800 mcg.**
2 mg.
What Is It?
Uses For B12 Folic™
What Is The Source?
Recommendations
Are There Any Potential Side Effects Or Precautions?
Are There Any Potential Drug Interactions?
References:
each vegetable capsule contains:
methylcobalamin (B12)
800 mcg.
folic acid
vitamin C (as ascorbyl palmitate)
(hypo-allergenic plant fiber
added to complete capsule volume requirement)
**Provides the recommended dose for pregnant or lactating women.
1–2 capsules per day, in divided doses, with meals.
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