
Forskolin
Life Extension, 10 mg, 60 capsules
In India, practitioners of traditional Ayurvedic medicine have long used the herb Coleus forskohlii to treat asthma, heart disease, and a range of other ailments. The small mint-family herb is also found in Sri Lanka, Thailand, and Nepal.
In the 1970s, researchers isolated a chemically active ingredient in the herb and called it forskolin. Now available in supplement form, this extract is commonly recommended for treating hypothyroidism, a condition in which the thyroid gland produces too little thyroid hormone. Forskolin is believed to stimulate the release of thyroid hormone, thus relieving such hypothyroidism symptoms as fatigue, depression, weight gain, and dry skin. Specifically, forskolin is thought to increase thyroid function by activating an enzyme that raises levels of a key cell-regulating substance called cAMP (cyclic adenosine monophosphate).
In addition to hypothyroidism, a number of other seemingly unrelated conditions have been linked to low levels of cAMP and may theoretically respond to forskolin treatment. These include asthma, heart disease, high blood pressure, glaucoma, eczema, and psoriasis. Countless laboratory and small-animal studies have been done to examine the benefits of forskolin for these disorders, but none have apparently been conducted in humans so far.
Forskolin is typically taken over the long-term for hypothyroidism; it should not be used in addition to thyroid hormone replacement therapy, however.
The basic mechanism of action of forskolin is the activation of an enzyme, adenylate cyclase, which increases cyclic adenosine monophosphate (cAMP) in cells.1 Cyclic AMP is perhaps the most important cell-regulating compound. Once formed it activates many other enzymes involved in diverse cellular functions.
1-Seamon KB, Padgett W, Daly JW. Forskolin: unique diterpene activator of adenylate cyclase in membranes and in intact cells. Proc Natl Acad Sci U S A. 1981 Jun;78(6):3363-7.
Supplement Facts
Serving Size 1 capsule
Servings Per Container 60
Amount Per Serving
Coleus forskohii (root) extract powder: 100 mg
10% forskolin (10 mg)
Other ingredients: rice flour, gelatin and water.
This product contains NO sugar, yeast, wheat, gluten, corn or dairy. Contains NO artificial color, sweeteners, flavors or preservatives.
Dosage and Use
One capsule per day is suggested for the first two weeks. An additional capsule can then be taken daily for the following two weeks if needed.
Caution
Do not take forskolin if you have existing prostate cancer since it may promote androgen-receptor activity on prostate cancer cells.
If you want to use forskolin to replace antihypertensive drugs, extreme caution is mandatory and physician cooperation is essential. Reduce the dosage of your antihypertensive drugs slowly, while increasing your intake of forskolin and monitor your blood pressure on a daily basis, otherwise an acute hypertensive event could occur, resulting in a stroke.
If you want to use forskolin to replace drugs that strengthen heart muscle contraction, extreme caution is also mandatory and physician cooperation essential. Numerous cardiac tests should be conducted to make sure forskolin is helping to maintain adequate cardiac output.
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