
Gluco-Flex Forte™, provided by Douglas
Laboratories, is a synergistic blend of glucosamine sulfate, n-acetyl
glucosamine and bovine cartilage. The combination of these products has
been carefully formulated and specifically designed to help maintain the
structure and function of healthy joints. Glucosamine is a naturally occurring amino sugar
found in glycosoaminoglycans (mucopolysaccharides), integral components of the
proteoglycans found in joint cartilage. Proteoglycans are large carbohydrate
rich structures that provide resiliency, load distribution, shock-absorbing,
compressive and lubricating properties to joints and connective tissues. Dietary
glucosamine serves as an immediate precursor for glycosaminoglycan synthesis,
and also stimulates incorporation of other precursors into the connective tissue
matrix. The availability of glucosamine is an integral part of the synthesis of
glycosaminoglycans and proteoglycans that are necessary during the constant
remodeling that aging cartilage undergoes. Thus, the maintenance of healthy
aging cartilage may be improved with enhanced deposition of glycosaminoglycans
and proteoglycans. Bioavailability of oral glucosamine sulfate is excellent. It
is absorbed intact, and utilized very quickly by all tissues, including
connective tissues. Both n-acetyl glucosamine and glucosamine sulfate have shown
in studies to be effective sources of glucosamine for glycosaminoglycan and
proteoglycan synthesis in all connective tissues, such as cartilage, ligaments,
tendons, skin, and bone. Chondroitin, a component of bovine cartilage, a
glycosaminoglycan formed in the body, is also used for the synthesis and
maintenance of connective tissue, primarily within the cartilage matrix. In
addition, chondroitin protects existing cartilage by reducing water loss from
the matrix and by inhibiting the enzymatic breakdown of the cartilage. The
overlapping activities as well as functional differences of glucosamine and
chondroitin offer several advantages for combined supplementation. Although
glucosamine is a precursor for chondroitin synthesis, this process requires
large amounts of metabolic energy. Dietary preformed chondroitin spares the use
of glucosamine for this purpose. Instead, glucosamine can be used for formation
of other important glycosaminoglycans and proteoglycans. When adequate
chondroitin is thus available to help protect tissues from premature breakdown,
glucosamine can more readily stimulate synthesis of healthy new tissue. Gluco-Flex Forte™ may be a useful nutritional
adjunct for individuals who wish to support the body’s connective tissues, such
as skin, tendons, ligaments, bone, and cartilage. Adults take 1 capsule daily with meals or as
directed by physician. No adverse side effects reported. Store in a cool, dry place, away from direct
light. Keep out of reach of children. Böhmer D, Ambrus P, Szögy A, and Haralambie G. Treatment of
chondropathia patellae in young athletes with glucosamine sulfate. In:
Current Topics Sports Medicine (Bachl N et al., eds.) Urban & Schwarzenberg,
Vienna, 1984, p.799. Crolle G, and D’Este E. Glucosamine sulfate for the
management of arthrosis: a controlled clinical investigation. Curr. Res.
Med. Opin. 1980; 7:104. D’Ambrosio E, Casa B, Bompani R, Scali G, and Scali
R.Glucosamine sulfate: a controlled clinical investigation in arthrosis.
Pharmatherapeutica 1981; 2:504. Drovanti A, Bignamini AA, and Rovati AL. Therapeutic
activity of oral glucosamine sulfate in osteoarthritis: a placebo-controlled
double-blind investigation. Clin. Ther. 1980; 3:260. Engel M, Maurel P, Margolis RK .Chondroitin sulfate
proteoglycans in the developing central nervous system. I. Cellular sites of
synthesis of neurocan and phosphacan. J Comparative Neurology
1996;366:34-43. Lopes Vaz A. Double-blind clinical evaluation of the
relative efficacy of ibuprofin and glucosamine sulfate in the management of
osteoarthrosis of the knee in outpatients. Curr. Res. Med. Opin.1982; 8:145
McCarty MF. Glucosamine for wound healing. Medical
Hypothesis 1996;47:273-275. Morreale P, et al. Comparison of the antiinflammatory
efficacy of chondroitin sulfate and diclofenac sodium in patients with knee
osteoarthritis. J Rheumatol 1996;23:1385-91. Piptone VR. Chondroprotection with chondroitin sulfate.
Drugs Exp Clin Res 1991;17 (1):3-7. Pujalte JM, et al. Double-blind clinical evaluation of oral
glucosamine sulfate in the basic treatment of osteoarthrosis. Curr Med Res
Opin 1980;7:110-114. Tapadinhas MJ, Rivera IC, Bignamini AA. Oral glucosamine
sulfate in the management of arthrosis: report on a multi-centre open
investigation in Portugal.1982;3(3):157-168. *These statements have not been evaluated by the Food and Drug
Administration. This product is not intended to diagnose, treat, cure, or
prevent any disease.
Description
Functions
Indications
Suggested Use
Side Effects/Warnings
Storage
References:
Each Capsule
Contains:
N-Acetyl Glucosamine
250 mg
Bovine Cartilage
100 mg
Glucosamine Sulfate
250 mg
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