
Melatonin capsules, as provided by Douglas
Laboratories®, contain 3 mg of highest purity melatonin produced under strict
Good Manufacturing Practices (GMP) standards. Melatonin is a natural hormone nutrient that is
synthesized from the amino acid tryptophan by the pineal gland in the back of
the brain. Melatonin also occurs in small amounts in a variety of foods. In the
body, melatonin appears to regulate sleep/wake cycles, support normal immune
function, and protect cells from free radical damage. Most of the research on
melatonin has focused on its role in maintaining normal sleep/wake rhythms. The
perception of daylight in the eyes is a signal for the pineal gland to inhibit
melatonin synthesis and release. At night or in the dark, the body’s melatonin
production rises. The rise in plasma melatonin is thought to be responsible for
bringing on sleep. Nocturnal melatonin production is highest in children and
begins to decline from adolescence on until it is virtually absent in the
elderly. Melatonin supports normal immune function by
helping maintain the activity of circulating natural killer cells. It also has
been found to function as an antagonist for stress-induced immunosuppression.
Melatonin is considered a potent antioxidant that enters all body cells to help
prevent free radical damage. In the brain, melatonin is perhaps the most
important physiological antioxidant. Due to its lipid and water-soluble
properties, it can freely cross the blood-brain barrier. In vitro studies show
that melatonin is more effective than glutathione in scavenging toxic hydroxyl
radicals, and also more efficient than vitamin E in neutralizing peroxyl
radicals which can induce DNA damage. Furthermore, melatonin stimulates the main
antioxidant enzyme of the brain, glutathione peroxidase. Melatonin capsules may be a useful nutritional
adjunct for individuals who wish to support the body’s pineal gland function. As a dietary supplement, take one capsule before
bedtime as needed or as directed by a physician. Warning: Not to be taken by individuals under the age of
18. If you are pregnant, nursing, taking any prescription medication (especially
hormone replacement therapy), or have an autoimmune or depressive disorder
consult a physician before using this product. Long-term use of melatonin has
not been studied. Use of this product could cause hypothermia. Do not use before
or while operating a motor vehicle or heavy machinery. Store in a cool, dry place, away from direct
light. Keep out of reach of children. Alvarez B, Dahlitz M, Vignau J, Parkes JD: The delayed sleep
phase syndrome: Clinical and investigative findings in 14 patients. J Neurol
Neurosurg Psychiatry 1992;55:665-670. Armstrong SM, Redman JR: Melatonin: A chronobiotic with
anti-aging properties? Med Hypotheses 1991;34:300-309. Beck-Friis J, Kjellman BF, Aperia B et al: Serum melatonin
in relation to clinical variables in patients with major depressive disorder
and a hypothesis of a low melatonin syndrome. Acta Psychiatr Scand
1985;71:319-330. Bismar K, Morgensen L, Wetterberg L: Depressed melatonin
secretion in patients with nightmares due to beta-adrenoceptor blocking
drug. Acta Med Scand 1987;221:155-158. Dahlitz M, Alvarez B, Vignau J et al: Delayed sleep phase
syndrome response to melatonin. Lancet 1991;337:1121-1124. Lieberman HR: Behavior, sleep and melatonin. J Neural Transm
Suppl 1989;21:233-241. Lissoni P, Barni S, Cattaneo G et al: Clinical results with
the pineal hormone melatonin in advanced cancer resistant to standard
antitumor therapies. Oncology 1991;48:448-450. Maestroni GJM, Conti A, Pierpaoli W: Role of the pineal
gland in immunity: Circadian synthesis and release of melatonin modulates
the antibody response and antagonizes the immunosuppressive effect of
corticosterone. J Neuroimmunol 1986;13:19-30. Maurizi CP: The therapeutic potential for tryptophan and
melatonin: possible roles in depression, sleep, Alzheimer’s disease and
abnormal aging. Med Hypotheses 1990;31:233-242. Petrie K, Conaglen JV, Thompson L, Chamberlain K: Effect of
melatonin on jet lag after long haul flights. Br Med J 1989;298:705-707.
Petrie K, Dawson AG, Thompson L, Brook R: A double-blind
trial of melatonin as a treatment for jet lag in international cabin crew.
Biol Psychiatry 1993;33:526-530. Waldhauser F, Weiszenbacher G, Tatzer E et al: Alterations
in nocturnal serum melatonin levels in humans with growth and aging. J Clin
Endocrinol Metab 1988;66:648-652. Waldhauser F, Waldhauser M, Lieberman HR et al:
Bioavailability of oral melatonin in humans. Neuroendocrinology
1984;39:307-313. *These statements have not been evaluated by the Food and Drug
Administration. This product is not intended to diagnose, treat, cure, or
prevent any disease.
Description
Functions
Indications
Suggested Use
Side Effects/Warnings
Storage
References:
Each capsule
contains:
Melatonin
2 mg
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