
5-Hydroxytryptophan (5-HTP) is an intermediate in
the natural synthesis of the essential amino acid, tryptophan, to serotonin.
Clinical studies suggest that 5-HTP supports healthy serotonin levels. In the
body, 5-HTP converts to serotonin with the enzymatic removal of a carboxyl group
(COOH). Serotonin is an important neurotransmitter involved in the regulation of
endocrine and brain activity responsible for emotion, appetite and sleep/wake
cycles.* Emotional Well-Being: Two open trials and a
double blind comparative investigation indicate that 5-HTP provides promising
support for emotional well-being. Additional studies indicate similar potential
for support.* Appetite And Weight Management Support:
5-HTP has been shown to help moderate appetite and food cravings in study
participants.* Cranial Vessel Comfort: In several trials,
including one that involved over 100 subjects, 5-HTP has demonstrated the
ability to promote healthy cranial vessel comfort and function.* 5-HTP is derived from the Griffonia simplicifolia
plant. Hypo-allergenic plant fiber is derived from pine cellulose. Pure Encapsulations recommends 50-300 mg per day,
in divided doses, before meals. Not to be taken by pregnant or lactating women.
5-HTP may cause gastrointestinal upset in sensitive individuals. Do not use concurrently with SSRI medications or
MAO inhibitors. Zmilacher K, Battegay R, Gastpar M. L-5-hydroxytryptophan
alone and in combination with a peripheral decarboxylase inhibitor in the
treatment of depression. Neuropsychobiology. 1988;20(1):28-35. Angst J, Woggon B, Schoepf J. The treatment of depression
with L-5- hydroxytryptophan versus imipramine. Results of two open and one
doubleblind study. Arch Psychiatr Nervenkr. 1977 Oct 11;224(2) 175-86. Cangiano C, Laviano A, Del Ben M, Preziosa I, Angelico F,
Cascino A, Rossi-Fanelli F. Effects of oral 5-hydroxy-tryptophan on energy
intake and macronutrient selection in non-insulin dependent diabetic
patients. Int J Obes Relat Metab Disord 1998. Jul;22(7):648-54. Ceci F, Cangiano C, Cairella M, et al. The effects of oral
5-hydroxytryptophan administration on feeding behavior in obese adult female
subjects. J Neural Transm 1989;76(2):109–17. Cangiano C, Ceci F, Cascino A, et al. Eating behavior and
adherence to dietary prescriptions in obese adult subjects treated with
5-hydroxytryptophan. Am J Clin Nutr 1992;56:863–7. Titus F, Davalos A, Alom J, Codina A. 5-hydroxytryptophan
versus methysergide in the prophylaxis of migraine. Eur Neurol
1986;25:327–9. Healthnotes Clinical Essentials. Copyright 2004. Healthnotes,
Inc.
What Is It?
Uses For 5-HTP
What Is The Source?
Recommendations
Are There Any Potential Side Effects Or Precautions?
Are There Any Potential Drug Interactions?
References:
each vegetable capsule contains:
5-hydroxytryptophan (Griffonia simplicifolia)
50 mg.
(hypo-allergenic plant fiber
added to complete capsule volume requirement)
Not to be taken by pregnant or lactating women. Do not use concurrently with SSRI medications or MAO inhibitors.
1–6 capsules per day, in divided doses, before meals.
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