Calcium D-Glucarate 500 mg 90 caps (Categories / Female Health) -- The Green Pharmacy Shopping Cart -- caps 90 mg 500 D-Glucarate Calcium

<A HREF="http://www.thegreenpharmacy.com" TITLE="The Green Pharmacy"><IMG SRC="https://store.nexternal.com/greenpharm/Logo-9thvector_Nexternal.jpg" ALT="The Green Pharmacy" NAME="The Green Pharmacy" BORDER=0></A> <H1>Calcium D-Glucarate 500 mg 90 caps -- The Green Pharmacy Shopping Cart</H1> $43.50 -- Naturally Enhancing Glucuronidation – A Detoxification System <IMG SRC="https://store.nexternal.com/greenpharm/images/DL_Calcium_D_Glucarate.jpg" ALIGN=right ALT="Calcium D-Glucarate 500 mg 90 caps" NAME="Calcium D-Glucarate 500 mg 90 caps" BORDER=0 HSPACE=10> <style>  </style> <h5 ALIGN="LEFT">Description</h5> Calcium D-Glucarate, provided by Douglas Laboratories, is a natural supplement of D-glucaric acid bound to calcium. <h5 ALIGN="LEFT">Functions</h5> Calcium D-glucarate enhances the body’s natural defenses against environmental toxins and excess steroid hormones. Through the actions of its metabolite D-glucaro-1,4-lactone, calcium-d-glucarate indirectly favors glucuronidation, an important system that the body relies upon to deactivate and eliminate toxins and steroid hormones. Glucuronidation is a conjugation process through which potentially carcinogenic environmental toxins, such as polycyclic aromatic hydrocarbons and nitrosamines, and excess steroid hormones are  neutralized. During glucuronidation, the enzyme glucuronosyl transferase catalyzes the conjugation of free carcinogens and steroid hormones to glucuronic acid. The resulting glucuronide-bound toxins and hormones can then be safely excreted in bile and urine. The body also deconjugates glucuronide-bound end products. The release of glucuronide-bound substances is beneficial in some circumstances, for example, when the excretion of steroid hormones is undesirable. Yet, the deconjugation process, which works via the enzyme beta-glucuronidase, can result in the re-release of harmful toxins back into the body. The benefits of calcium D-glucarate are realized indirectly through the action of its metabolite Dglucaro- 1,4-lactone, which inhibits the deconjugating enzyme beta-glucuronidase found in both blood and tissue. Inhibition of beta- lucuronidase causes a net increase in glucuronidation, and thereby enhances a primary detoxification pathway in the body. Animal studies have documented a decrease in B-glucuronidase activity in breast, liver, colon, skin, lung, and prostate tissue following oral administration of calcium Dglucarate. Once ingested, calcium D-glucarate is converted to Dglucaric acid in the presence of gastric HCl. The body normally maintains an equilibrium between D-glucaric acid and its two metabolites, D-glucaro-1,4-lactone and D-glucaro-6,3-lactone. Calcium D-glucarate provides a slow-release source of D- lucaro-1,4-lactone. When taken directly, D-glucaro- 1,4-lactone is metabolized quite quickly and is excreted from the body usually within 1-2 hours of its administration. Calcium D-glucarate, however, is metabolized slowly, remaining in the body for 5 or more hours after ingestion. This results in maintenance of stable levels of D-glucaro-1,4-lactone for long periods of time. D-glucaric acid is produced endogenously in small amounts. It is also present in some fruits and vegetables, including oranges, apples, grapefruit, broccoli and other cruciferous vegetables. <h5 ALIGN="LEFT">Indications</h5> Calcium D-Glucarate may be a useful dietary supplement for those who wish to supplement their diet with D-glucaric acid as a precursor to D-glucaro- 1, 4-lactone. <h5 ALIGN="LEFT">Suggested Use</h5> One to two capsules daily as a dietary supplement, or as directed by physician. <h5 ALIGN="LEFT">Side Effects/Warnings</h5> No adverse effects have been reported. <h5 ALIGN="LEFT">Storage</h5> Store in a cool, dry place, away from direct light. Keep out of reach of children. <h5 ALIGN="LEFT">References:</h5> <ol> <li> Abou-Issa H, Moeschberger M, el-Masry W, et al. Relative efficacy of glucarate on the initiation and promotion phases of rat mammary carcinogenesis. Anticacner Res 1995;15(3):805-10. </li> <li> Abou-Issa H, Koolemans-Beyen A, Meredith TA, Webb TE. Antitumor synergism between non-toxic dietary combinations of isoretinoin and glucarate. Eur J Cancer 1992;28A(4-5):784-8. </li> <li> Abou-Issa HM, Duruibe VA, Minton JP, et al. Putative metabolites derived from dietary combineations of caclium glucarate and N-(4- hydroxyphenyl)retinaminde act synergistically to inhibit the induction of rat mammary tumors by 7,12-dimethylbenz[a]antracene. Proc Natl Acad Sci USA 1988;85(12):4181-4. </li> <li> Dwivedi C, Heck WJ, Downie AA, et al. Effect of calcium glucarate on beta-glucuronidase activity and glucarate content of certain vegetables and fruits. Biochem Med Metab Biol 1990;43(2):83-92. </li> <li> Dwivedi C, Oredipe OA, Barth RF, et al. Effects of the esperimental chemopreventive agent, glucarate, on intestinal carcinogenesis in rats. Carcinogenesis 1989;10(8):1539-41. </li> <li> Heerdt AS, Young CW, Borgen PI. Calcium glucarate as a chemopreventive agent in breast cancer. Isr J Med Sci 1995;31:101-105. </li> <li> Oredipe OA, Barth RF, Dwivedi C, Webb TE. Dietary glucaratemediated inhibition of diethylnitrosamine-induced hepatocarcinogenesis. Toxicology 1992;74(2-3):209-22. </li> <li> Oredipe OA, Barth RF, Hanausek-Walaszek M, et al. Effects of calcium glucarate on the promotion of diethylnitrosamine-initiated altered hepatic foci in rats. Cancer Lett 1987;38(1-2):95-9. </li> <li> Oredipe OA, Barth RF, Dwivedi C, Webb TE. Chemopreventive activity of dietary glucarate on azoxymethane-induced altered hepatic foci in rats. Res Commun Chem Pathol Pharmacol 1989;65(3):345- 9. </li> <li> Walaszek Z, Szemraj J, Narog M, et al. Metabolism, uptake, and excretion of a D-glucaric acid salt and its potential use in cancer prevention. Cancer Detect Prev 1997;21(2):178-90. </li> <li> Walaszek Z, Hanausek-Walaszek M, Webb TE. Dietary glucaratemediated reduction of sensitivity of murine strains to chemical carcinogenesis. Cancer Lett 1986;33(1):25-32. </li> <li> Walaszek Z, Hanausek M, Sherman U, Adams AK. Antiproliferative effect of dietary glucarate on the Sprague-Dawley rat mammary gland. Cancer Lett 1990;49(1):51-7. </li> <li> Webb TE, Pham-Nguyen MH, Darby M, Hamme AT 2nd. Pharmacokinetics relevant to the anti-carcinogenic and anti-tumor activities of glucarate and the synergistic combination of glucarate:retinoid in the rat</li> </ol> Each capsule contains:<table width="351" cellpadding="0" cellpadding="0"> <tr> <td width="270" background="/images/dots2.gif" nowrap> Calcium D-Glucarate</td><td width="75" background="/images/dots2.gif" align="right" nowrap> 500 mg</td></tr> </table> *These statements have not been evaluated by the Food and Drug Administration. 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