
Cat's claw (Uncaria tomentosa) is an herb found in
the highlands of Peru's Amazon rainforest. Known in Peruvian traditional
medicine as Uña de Gato, cat's claw has been used as a medicinal herb with
almost panacea like qualities. It may be therapeutically useful for a range of
health problems including those associated with a weakened immune system. Peruvian Ashaninka Indian priests have
traditionally used cat's claw to regulate what they perceive as the dynamic
interaction between an individual's physical and spiritual well being. Modern
Western science has identified in cat's claw extract alkaloids that may be
responsible for its reputed curative powers. The alkaloids in cat's claw have
been shown in scientific studies to be effective immunostimulants. In
particular, the pentacyclic oxindole alkaloid, isopteropodine, enhances
phagocytic activity of white blood cells. Extracts of cat’s claw also stimulate
production of interleukin-1 and -6 in alveolar macrophages, suggesting a strong
immunostimulant effect. These alkaloids also stimulate the production of
lymphocyte proliferation regulating factor, which modulates the total number of
leucocytes available for an immune response. The alkaloids in cat's claw extract
are effective not only in the inhibition of platelet aggregation and associated
thrombosis, but also in protection of cells against destructive oxidative damage
and inflammation by inhibiting iNOS gene expression and activation of NF-kappaB. Cat’s Claw Max-V capsules may be a useful dietary
supplement for those who wish to improve their immune functioning. Adults take 1 to 2 capsules daily between meals or
as directed by physician. No adverse effects have been reported. Store in a cool, dry place, away from direct
light. Keep out of reach of children. Aquino R, De Simone F, Pizza C, et al. Plant metabolites.
Structure and in vitro antiviral activity of quinovic acid glycosides from
Uncaria tomentosa and Guettarda platypoda. J Nat Prod 1989;52:679- 5. Keplinger K, Laus G, Wurm M, et al. Uncaria tomentosa (Willd.)
DC.--ethnomedicinal use and new pharmacological, toxicological and botanical
results. J Ethnopharmacol 1999;64:23-34. Lemaire I, Assinewe V, Cano P, et al. Stimulation of
interleukin-1 and -6 production in alveolar macrophages by the neotropical
liana, Uncaria tomentosa (una de gato). J Ethnopharmacol 1999;64:109- 5.
Reinhard KH. Uncaria tomentosa (Willd.) D.C.: cat's claw,
una de gato, or saventaro. J Altern Complement Med 1999;5:143-51. Rizzi R, Re F, Bianchi A, et al. Mutagenic and antimutagenic
activities of Uncaria tomentosa and its extracts. J Ethnopharmacol
1993;38:63-77. Sandoval-Chacon M, Thompson JH, Zhang XJ, et al.
Antiinflammatory actions of cat's claw: the role of NF-kappaB. Aliment
Pharmacol Ther 1998;12:1279-89. Senatore A, Cataldo A, Iaccarino FP, et al. [Phytochemical
and biological study of Uncaria tomentosa]. Boll Soc Ital Biol Sper
1989;65:517-20. Sheng Y, Pero RW, Amiri A, et al. Induction of apoptosis and
inhibition of proliferation in human tumor cells treated with extracts of
Uncaria tomentosa. Anticancer Res 1998;18:3363-8. Sheng Y, Bryngelsson C, Pero RW. Enhanced DNA repair, immune
function and reduced toxicity of C-MED-100, a novel aqueous extract from
Uncaria tomentosa. J Ethnopharmacol 2000;69:115-26. Wurm M, Kacani L, Laus G, et al. Pentacyclic oxindole
alkaloids from Uncaria tomentosa induce human endothelial cells to release a
lymphocyte-proliferation-regulating factor. Planta Med 1998;64:701-4. *These statements have not been evaluated by the Food and Drug
Administration. This product is not intended to diagnose, treat, cure, or
prevent any disease.
Description
Functions
Indications
Suggested Use
Side Effects/Warnings
Storage
References:
Each Vcaps™
Vegetarian Capsule Contains:
Cat’s Claw (Uncaria tomentosa)
250 mg
Standardized to 3.0%
alkaloids and 15% total
polyphenols
(Amazonian Peru)
In a 100 mg base of
non-standardized Cat's Claw.
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