
Calcigard® 250, manufactured by Douglas
Laboratories®, provides 250 mg of elemental calcium from calcium citrate.
Calcigard 250 is available with and without added vitamin D. The adult human body contains approximately 1,200
g of calcium, of which about 99% is present in the skeleton. Bone is constantly
turning over, through a continuous process of formation and resorption. In
children and adolescents, the rate of formation of bone mineral predominates
over the rate of resorption. In later life, resorption predominates over
formation. Therefore, in normal aging, there is a gradual loss of bone. The
remaining 1% of total body calcium is found in the soft tissues and plays
important roles in such vital functions as nerve conduction, muscle contraction,
blood clotting, membrane permeability, and hormonal signaling. Blood calcium
levels are carefully maintained within very narrow limits by the interplay of
several hormones (1,25-dihydroxy-cholecalciferol, parathyroid hormone,
calcitonin, estrogen, and testosterone) which control calcium absorption and
excretion, as well as bone metabolism. Levels of soft tissue calcium are
maintained at the expense of bone calcium in the face of inadequate calcium
intake or absorption. Intestinal calcium absorption is generally higher in
children than in adults and ranges from 15 to 75% of ingested calcium. Adequate
vitamin D status is necessary for normal calcium absorption. Osteoporosis
afflicts a large proportion of the elderly in developed countries. Caucasian and
Asian women typically have low peak bone densities, and therefore, are at the
greatest risk of developing osteoporosis. It is generally accepted that
obtaining enough dietary calcium throughout life can significantly decrease the
risk of developing osteoporosis. Among other factors, such as regular exercise,
gender and race, calcium supplementation during childhood and aldolescence
appears to be a prerequisite for maintaining adequate bone density later in
life. But even elderly osteoporotic patients can benefit significantly from
supplementation with dietary calcium. Calcigard 250 provides calcium citrate
which is a highly available and well tolerated source of dietary calcium.
Vitamin D is a key regulatory hormone for calcium and bone metabolism. Adequate
vitamin D intake is important for ensuring normal calcium absorption and
maintaining proper calcium plasma levels. People living in southern regions of
the U.S. can derive significant amounts of vitamin D from sunlight dependent
synthesis in the skin during the summer, whereas people in the northern states
have to rely more on foods and supplements for adequate vitamin D status. This
is why Calcigard 250 is available both with (CA2) and without (CA1) vitamin D. Calcigard 250 may be a useful dietary supplement
for those at risk for osteoporosis, or anyone who wishes to increase their
intake of calcium and other nutritional factors for maintaining good bone
health. One to four tablets daily as a dietary supplement,
or as directed by a physician. Take with food. No adverse side effects have been reported. Store in a cool, dry place, away from direct
light. Keep out of reach of children. Andon MB, Lloyd T, Matkovic V. Supplementation trials with
calcium citrate malate: Evidence in favor of increasing the calcium RDA
during childhood and adolescence. J Nutr 1994;124 Suppl.1412S- 417S. Barger-Lux MJ, Heaney RP. The role of calcium intake in
preventing bone fragility, hypertension, and certain cancers. J Nutr
1994;124 Suppl.1406S-1411S. Belizan JM, Villar J, Bergel E, Pino Ad, Di Fulvio S,
Galliano SV, and Kattan C. Long term effect of calcium supplementation
during pregnancy on the blood pressure of offspring: follow up of a
randomised controlled trial. BMJ 1997;315(7013):281-5. Bronner F. Calcium and osteoporosis. Am J Clin Nutr
1994;60:831- 836. Fleming KH, Heimbach JT. Consumption of calcium in the U.S.:
Food sources and intake levels. J Nutr 1994;124 Suppl.1426S-1430S. Gillman MW, Hood MY, Moore LL, Nguyen U-SDT, Singer MR,
Andon MB. Effect of calcium supplementation on blood pressure in children. J
Pediatr 1995;127:186-192. Horowitz M, Wishart JM, Goh D, Morris HA, Need AG, Nordin
BEC. Oral calcium suppresses biochemical markers of bone resorption in
normal men. Am J Clin Nutr 1994;60:965-968. Ito M, Koyama H, Ohshige A, Maeda T, Yoshimura T, Okamura H.
Prevention of preeclampsia with calcium supplementation and vitamin D3 in an
antenatal protocol. Int J Gynecol Obstet 1994;47:115- 20. Lee WTK, Leung SSF, Wang S-H, et al. Double-blind,
controlled calcium supplementation and bone mineral accretion in children
accustomed to a low-calcium diet. Am J Clin Nutr 1994;60:744-750. Levine BS, Rodman JS, Wienerman S, Bockman RS, Lane JM,
Chapman DS. Effect of calcium citrate supplementation on urinary calcium
oxalate saturation in female stone formers: Implications for prevention of
osteoporosis. Am J Clin Nutr 1994;60:592-596. Miller GD, Weaver CM. Required versus optimal intakes: A
look at calcium. J Nutr 1994;124 Suppl.1404S-1405S. Pak CYC, Stewart A, Haynes SDS. Effect of added citrate or
malate on calcium absorption from calcium-fortified orange juice. J Am Coll
Nutr 1994;13:575-577. Reid IR, Ames RW, Evans MC, Gamble GD, Sharpe SJ. Long-term
effects of calcium supplementation on bone loss and fractures in
postmenopausal women: A randomized controlled trial. Am J Med
1995;98:331-335. Strause L, Saltman P, Smith KT, Bracker M, Andon MB. Spinal
bone loss in postmenopausal women supplemented with calcium and trace
minerals. J Nutr 1994;124:1060-1064. Teegarden D, Weaver CM. Calcium supplementation increases
bone density in adolescent girls. Nutr Rev 1994;52:171-173. *These statements have not been evaluated by the Food and Drug
Administration. This product is not intended to diagnose, treat, cure, or
prevent any disease.
Description
Functions
Indications
Suggested Use
Side Effects/Warnings
Storage
References:
Each tablet
contains:
Calcium (citrate)
250 mg**
Vitamin D3 (fish liver oil)***
50 IU
**elemental content
***optional ingredient
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